CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD449
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Sildenafil Family
No. of Seeds 17 No. of Other Members 40
Family Centroid CFAMM00061511 Functional Category Approved Drug with Human Metabolite
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Sildenafil Superfamily
Class Class 363

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Vardena... 3 39
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor UK-3690... 35 10
Extracellular calcium-sensing receptor ligand (5R)-N-[3-(4-eth... 6 7
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor N-[3-(1... 26 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 1,3-dim... 3 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 1,3-dim... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor (5Z)-1-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00061513 DAP000960 Approved Drug Udenafil
CFAMM00061511 DAP000614 Approved Drug Sildenafil
CFAMM00061521 CHEMBL53538 Bioactive Hydroxyhomo Sildenafil
CFAMM00061514 CHEMBL245323 Bioactive [1-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]methylphosphonic acid
CFAMM00061506 CHEMBL457207 Bioactive 1-[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]sulfonylpiperidine-4-carboxamide
CFAMM00061520 CHEMBL394040 Bioactive 5-[5-[4-(diethoxyphosphorylmethyl)piperidin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00061478 CHEMBL245721 Bioactive 2-[4-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]ethylphosphonic acid
CFAMM00061519 CHEMBL1737 Bioactive Sildenafil citrate
CFAMM00061477 CHEMBL245922 Bioactive [1-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]phosphonic acid
CFAMM00061502 CHEMBL246536 Bioactive 5-[5-[4-(2-diethoxyphosphorylethyl)piperazin-1-yl]sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00061482 CHEMBL245317 Bioactive ethoxy-[[1-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]methyl]phosphinic acid
CFAMM00061510 CHEMBL245522 Bioactive 5-[5-(4-diethoxyphosphorylpiperidin-1-yl)sulfonyl-2-propoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
CFAMM00061475 CHEMBL245517 Bioactive ethoxy-[[4-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]methyl]phosphinic acid
CFAMM00061532 CHEMBL541468 Bioactive ethoxy-[2-[4-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperazin-1-yl]ethyl]phosphinic acid
CFAMM00061481 CHEMBL245315 Bioactive ethoxy-[1-[3-(1-methyl-7-oxo-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxyphenyl]sulfonylpiperidin-4-yl]phosphinic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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