CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD450
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole alkaloid Tadalafil Family
No. of Seeds 28 No. of Other Members 2712
Family Centroid CFAMM00064635 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Tubulin, cyclic phosphodiesterase, amine transporter binding indole alkaloid Vindoline Tadalafil Reserpine Superfamily
Class Class 97

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
DNA Binder Primaquine Family 3 245
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Synaptic vesicular amine transporter inhibitor indole alkaloi... 3 11
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Na+-K+-ATPase transmembrane protein Inhibitor Sanguinarine Family 8 20
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Coagulation factor X Inhibitor Apixaban Family 34 52
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Apricoxib family 8 77
Indeglitazar family 3 39
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Integrin beta-3 Inhibitor L-756568 Family 8 59
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Metabotropic glutamate receptor 1 Ligand JNJ-16259685 Family 3 20
High affinity nerve growth factor receptor and Mitogen-activat... 2 7
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 15 28
Sigma non-opioid intracellular receptor 1 and Kappa-type opioi... 3 12
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 23 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... 2 12
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
5-hydroxytryptamine receptor 1A ligand (2S)-1-[(3S,4R)-3-(1,3-... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 0
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 4 4
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Cannabinoid receptor 1 ligand AGN-PC-088XYA family 4 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
Pol polyprotein and Cytochrome P450 3A4 inhibitor P3 arylpyrro... 19 1
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 21 11
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 2 9
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Glucocorticoid receptor ligand SureCN4194063 family 1 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Coagulation factor X and Prothrombin inhibitor AGN-PC-0759SH f... 5 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Sodium-dependent serotonin transporter inhibitor (4S)-4-[4-[(2... 1 3
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
NS5B protein inhibitor AC1O5AET family 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Renin and Potassium voltage-gated channel subfamily H member 2... 4 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Plasmepsin-1 and Cathepsin D inhibitor N-[(2S)-1-[[(2S,3S)-5-[... 2 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Sodium-dependent serotonin transporter and D(2) dopamine recep... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Microsomal triglyceride transfer protein large subunit inhibit... 9 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Cannabinoid receptor 1 ligand AGN-PC-0766FR family 4 3
Transient receptor potential cation channel subfamily V member... 1 5
Peroxisome proliferator-activated receptor delta and Peroxisom... 7 5
Beta-2 adrenergic receptor ligand SureCN5346426 family 8 0
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 1
Translocator protein inhibitor AGN-PC-07BUUF family 11 2
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta inhibitor 3-imidazo[1,2-a]pyri... 1 1
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 0
Transient receptor potential cation channel subfamily V member... 6 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 4
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 4
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 1 0
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-075BWR family 1 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Adenosine receptor A1 ligand BAS 00727702 family 1 4
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
DNA topoisomerase 1 inhibitor AC1LAHQQ family 5 14
Potassium voltage-gated channel subfamily A member 5 ligand AG... 1 0
Histone deacetylase 1 inhibitor (2S)-2-[[2-(5-methoxy-2-methyl... 2 2
Melanin-concentrating hormone receptor 1 ligand 6-[3-methoxy-4... 5 1
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
C-X-C chemokine receptor type 2 ligand 4-[5-cyano-2-(4-fluorop... 1 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 3 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Bile acid receptor ligand SureCN1243717 family 1 4
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5
Aurora kinase A inhibitor SureCN3802792 family 2 3
Telomerase reverse transcriptase inhibitor N-[9-(4-methoxyanil... 2 0
DNA polymerase beta and Cruzipain inhibitor CHEMBL1462186 family 1 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Nuclear receptor ROR-gamma and Microtubule-associated protein ... 1 6
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 3 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 2 0
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0
Beta-secretase 1 inhibitor 2-[2-(3-cyanophenyl)-5-(4-phenoxyph... 5 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 0
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0
Amino Acids and Derivatives Metabolite Flazine Family 3 2
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
NP (r)-methyl 2-(1-(3,4,5-trimethoxyphenyl)-9h-pyrido[3,4-b]in... 7 0
Putative NP ZINC20112899 Family 6 0
Putative NP ZINC12880788 Family 12 0
NP 3-(6-methoxy-3,4-dihydro-1h-pyrido[3,4-b]indol-2(9h)-yl)-1-... 1 0
2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-2-ium NP ZINC02119030... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00064635 DAP000615 Approved Drug Tadalafil
CFAMM00061609 CHEMBL34628 Bioactive CHEMBL34628
CFAMM00061619 CHEMBL285737 Bioactive CHEMBL285737
CFAMM00061688 CHEMBL2022209 Bioactive CHEMBL2022209
CFAMM00061738 CHEMBL284070 Bioactive CHEMBL284070
CFAMM00061754 CHEMBL33627 Bioactive CHEMBL33627
CFAMM00062303 CHEMBL33518 Bioactive CHEMBL33518
CFAMM00062594 CHEMBL342459 Bioactive CHEMBL342459
CFAMM00062662 CHEMBL141918 Bioactive CHEMBL141918
CFAMM00062805 CHEMBL328476 Bioactive AGN-PC-074Q3T
CFAMM00062978 CHEMBL32255 Bioactive SureCN4600914
CFAMM00063174 CHEMBL286309 Bioactive CHEMBL286309
CFAMM00063369 CHEMBL56159 Bioactive AGN-PC-074ADX
CFAMM00063585 CHEMBL343941 Bioactive CHEMBL343941
CFAMM00063736 CHEMBL434797 Bioactive SureCN1326701
CFAMM00063852 CHEMBL343553 Bioactive SureCN7440370
CFAMM00063876 CHEMBL140599 Bioactive CHEMBL140599
CFAMM00064407 CHEMBL33121 Bioactive CHEMBL33121
CFAMM00064409 CHEMBL336716 Bioactive SureCN7448564
CFAMM00064472 CHEMBL2022214 Bioactive CHEMBL2022214
CFAMM00064481 CHEMBL34276 Bioactive CHEMBL34276
CFAMM00064491 CHEMBL2022212 Bioactive CHEMBL2022212
CFAMM00064556 CHEMBL138466 Bioactive SureCN7449071
CFAMM00064618 CHEMBL141307 Bioactive SureCN1327475
CFAMM00064636 CHEMBL345179 Bioactive 3-(1,3-benzodioxol-5-yl)-2-(3-phenylpropanoyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00064652 CHEMBL34802 Bioactive CHEMBL34802
CFAMM00064934 CHEMBL33147 Bioactive CHEMBL33147
CFAMM00064971 CHEMBL2022215 Bioactive CHEMBL2022215