CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD456
Family Name Cyclooxygenase Inhibitor Flurbiprofen Family
No. of Seeds 18 No. of Other Members 294
Family Centroid CFAMM00066948 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Cyclooxygenase Inhibitor Flurbiprofen Superfamily
Class Class 368

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Retinoid X receptor Ligand Bexarotene Family 7 492
Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family 22 503
Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family 5 84
Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family 19 144
Muscarinic acetylcholine receptor Ligand Cyclopentolate Family 10 11
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
CPI-613 family 4 35
Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family 4 13
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU79256 F... 1 0
Beta-lactamase Inhibitor 4-carboxyphenylboronic Acid Family 1 1
Cathepsin L1 Inhibitor Biphenyl-4-yl-acetaldehyde Family 2 86
Carboxypeptidase B2 Inhibitor Dl-benzylsuccinic Acid Family 1 11
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Macrophage migration inhibitory factor Inhibitor 3,3,3-tris(4-... 4 16
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 2-(3-cyanobenzyl)-5-mer... 1 0
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
Calcium-activated potassium channel subunit alpha-1 Ligand Tri... 1 10
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Collagenase 3 and Macrophage metalloelastase Inhibitor 5-(4'-c... 4 43
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Lorneic... 1 1
Prostaglandin G/H synthase 1 Inhibitor 2-(3'-ethylsulfanyl-bip... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(ethoxycarbonyl)pheny... 2 69
Fatty-acid amide hydrolase 1 Inhibitor Btnp Family 1 7
Trypsin-1 and Prothrombin inhibitor (3S,3aR,6aS)-3-benzyl-3,3a... 2 23
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 2-[9-... 2 15
Free fatty acid receptor 1 and Free fatty acid receptor 4 liga... 1 7
Chymotrypsinogen B inhibitor (6E)-6-(iodomethylidene)-4-phenyl... 1 1
Glutamate carboxypeptidase 2 inhibitor SureCN5052894 family 1 17
Protease and Pol polyprotein inhibitor U-96988 family 3 15
Arachidonate 15-lipoxygenase inhibitor SureCN9469035 family 6 40
Free fatty acid receptor 1 ligand AGN-PC-0CCG7G family 1 2
Free fatty acid receptor 1 and Free fatty acid receptor 4 liga... 1 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 4
Peroxisome proliferator-activated receptor gamma ligand SureCN... 3 3
Retinal dehydrogenase 1 and Microtubule-associated protein tau... 1 7
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Beta-lactamase inhibitor CHEMBL1358094 family 1 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Metabotropic glutamate receptor 1 ligand SureCN186260 family 1 4
Sodium-dependent dopamine transporter inhibitor AGN-PC-074TA8 ... 2 5
Microtubule-associated protein tau and Putative fructose-1,6-b... 1 1
Squalene synthase inhibitor L-731120 family 2 1
Indanes Metabolite (R)-Pterosin B Family 5 8
Aromatic Homomonocyclic Compounds Metabolite Dimethylbenzyl ca... 2 11
Carboxylic Acids and Derivatives Metabolite 3-Acetoxy-3-methyl... 2 0
Phenylpropenes Metabolite alpha-Amylcinnamyl acetate Family 3 3
Putative NP ZINC35464636 Family 6 1
Putative NP ZINC14410655 Family 6 4
(1S)-1-hydroxy-1,4-dimethyl-2,3-dihydrocyclopenta[b]anthracene... 1 1
Putative NP ZINC06763537 Family 6 4
2-methyl-3-oxo-1-phenylcyclopentane-1-carboxylate NP ZINC02496... 4 1
7a-hydroxy-7-phenyl-3,3a,4,5,6,7-hexahydro-1-benzofuran-2-one ... 4 0
carboxylate NP ZINC04026424 Family 3 7
Putative NP ZINC02930279 Family 2 1
(1R,2S,4R,5R)-4-benzyl-2,5-dibromocyclohexane-1-carboxylate NP... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00066948 DAP000621 Approved Drug Flurbiprofen
CFAMM00067007 DAP000780 Approved Drug Ibuprofen
CFAMM00067127 CHEMBL175 Bioactive (S)-(+)-Ibuprofen
CFAMM00067199 CHEMBL1945285 Bioactive (2S)-3-fluoro-2-[4-(2-methylpropyl)phenyl]propanoic acid
CFAMM00066997 DNC005399 Investigative Drug 2-[3-(2-Methyl-butyl)-phenyl]-propionic acid
CFAMM00067012 DNC005788 Investigative Drug (S)-FLURBIPROFEN
CFAMM00066910 DNC012498 Investigative Drug 2-(3'-Allyl-biphenyl-4-yl)-propionic acid
CFAMM00067107 DNC002443 Investigative Drug 2-(1,1'-Biphenyl-4-Yl)Propanoic Acid
CFAMM00067018 DNC002823 Investigative Drug Diphenylacetic Acid
CFAMM00067082 DNC006444 Investigative Drug R-flurbiprofen
CFAMM00066946 DNC012505 Investigative Drug 2-(3'-Vinyl-biphenyl-4-yl)-propionic acid
CFAMM00067068 DNC002776 Investigative Drug RU78191
CFAMM00067169 DNC005400 Investigative Drug 2-[3-(1-Phenyl-ethyl)-phenyl]-propionic acid
CFAMM00066944 DNC012506 Investigative Drug 2-(3'-Ethyl-biphenyl-4-yl)-propionic acid
CFAMM00066999 DNC005397 Investigative Drug 2-(3-Isopropyl-phenyl)-propionic acid
CFAMM00066906 DNC011269 Investigative Drug fluoro loxoprofen
CFAMM00067015 DNC002451 Investigative Drug Flurbiprofen Methyl Ester
CFAMM00066998 DNC005398 Investigative Drug 2-(3-Isobutyl-phenyl)-propionic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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