CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD457
Family Name Cyclooxygenase Inhibitor Oxaprozin Family
No. of Seeds 33 No. of Other Members 450
Family Centroid CFAMM00067349 Functional Category Approved Drug with Natural Product
Superfamily Cyclooxygenase Inhibitor Oxaprozin Superfamily
Class Class 369

Cousin Family NamesSeedsMembers
Nitric oxide synthase, endothelial Inhibitor Acclaim Family 2 15
Egl nine homolog 2 Inhibitor FG-4592 Family 1 4
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Benoxapr... 1 76
Peroxisome proliferator-activated receptor alpha Ligand Alegli... 29 7
Substance-P receptor Ligand R 673 Family 2 127
FX005 family 2 1
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Peroxisome proliferator-activated receptor gamma Ligand SB-213... 2 54
Prostaglandin G/H synthase 2 Inhibitor Tilmacoxib Family 1 28
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Oestrogen receptor and Estrogen receptor beta Ligand 2-(6-hydr... 9 22
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[4-(4-hydroxyphe... 1 4
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
Peroxisome proliferator-activated receptor delta ligand AGN-PC... 7 27
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 7-[5... 1 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
Aldose reductase inhibitor SureCN1590315 family 1 7
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
Neprilysin and Natriuretic peptides A inhibitor (2S)-2-[[1-[[(... 3 3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin E2 receptor EP4 subtype ligand SureCN4876498 family 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor 4-[[(2S,4S)-4-f... 4 7
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[6-propan-2-ylo... 1 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 7 1
Sphingosine 1-phosphate receptor 1 ligand AGN-PC-00DWQL family 2 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Beta-secretase 1 and Cytochrome P450 3A4 inhibitor N-[(2S,3R)-... 3 7
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 5 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Peroxisome proliferator-activated receptor alpha ligand 5-[4-[... 1 0
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 1 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(2,6-di... 2 4
Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-04UH7Y family 4 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 0
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Peroxisome proliferator-activated receptor gamma and Tyrosine-... 1 0
Glucocorticoid receptor and Progesterone receptor ligand (8S,1... 2 0
Protein farnesyltransferase subunit beta and Protein farnesylt... 1 3
Cholesteryl ester transfer protein inhibitor AGN-PC-07R9U4 family 1 1
Arachidonate 5-lipoxygenase inhibitor (4E)-4-[(E,4Z)-4-(3H-1,3... 6 6
2-enenitrile NP ZINC05025155 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00067349 DAP000622 Approved Drug Oxaprozin
CFAMM00067733 CHEMBL200162 Bioactive SureCN821392
CFAMM00067524 CHEMBL247659 Bioactive SureCN6816953
CFAMM00067679 CHEMBL366138 Bioactive AGN-PC-03OADX
CFAMM00067709 CHEMBL231523 Bioactive (3E)-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-3-propoxyiminobutanoic acid
CFAMM00067593 CHEMBL231425 Bioactive (3E)-3-methoxyimino-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]butanoic acid
CFAMM00067504 CHEMBL256358 Bioactive 5-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1-(2-methylpropoxycarbonyl)-3,4-dihydro-2H-pyridine-4-carboxylic acid
CFAMM00067657 CHEMBL81248 Bioactive SureCN5113061
CFAMM00067650 CHEMBL230517 Bioactive (3E)-2-[[4-[2-[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]phenyl]methyl]-3-propoxyiminobutanoic acid
CFAMM00067317 CHEMBL246208 Bioactive SureCN820903
CFAMM00067656 CHEMBL398746 Bioactive 2-[(1S)-5-[2-(2-phenyl-5-propyl-1,3-oxazol-4-yl)ethoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
CFAMM00067467 CHEMBL82034 Bioactive AGN-PC-008ILZ
CFAMM00067296 CHEMBL467349 Bioactive SureCN4243493
CFAMM00067554 CHEMBL230705 Bioactive (3E)-3-butoxyimino-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]butanoic acid
CFAMM00067433 CHEMBL230409 Bioactive (3E)-3-ethoxyimino-2-[[4-[[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]phenyl]methyl]butanoic acid
CFAMM00067535 CHEMBL230814 Bioactive (3E)-3-ethoxyimino-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]pentanoic acid
CFAMM00067453 CHEMBL192613 Bioactive SureCN1626140
CFAMM00067553 CHEMBL230706 Bioactive (3E)-3-(cyclopropylmethoxyimino)-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]butanoic acid
CFAMM00067418 CHEMBL481549 Bioactive (4E)-4-[4-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]butoxyimino]-4-phenylbutanoic acid
CFAMM00067654 CHEMBL230518 Bioactive (3E)-3-(2-fluoroethoxyimino)-2-[[4-[2-[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]phenyl]methyl]butanoic acid
CFAMM00067220 CHEMBL257165 Bioactive 3-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1-(2-methylpropoxycarbonyl)piperidine-4-carboxylic acid
CFAMM00067552 CHEMBL230707 Bioactive (3E)-3-methoxyimino-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]pentanoic acid
CFAMM00067321 CHEMBL246203 Bioactive SureCN9909945
CFAMM00067334 CHEMBL388422 Bioactive (3E)-3-ethoxyimino-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]butanoic acid
CFAMM00067596 CHEMBL230305 Bioactive (3E)-3-ethoxyimino-2-[[4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl]methyl]butanoic acid
CFAMM00067286 CHEMBL388645 Bioactive (3E)-2-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-3-(2-methylpropoxyimino)butanoic acid
CFAMM00067704 CHEMBL199794 Bioactive SureCN4679187
CFAMM00067479 CHEMBL520272 Bioactive (4Z)-4-[5-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]pentoxyimino]-4-phenylbutanoic acid
CFAMM00067416 CHEMBL256142 Bioactive 5-[[3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1-propoxycarbonyl-3,4-dihydro-2H-pyridine-4-carboxylic acid
CFAMM00067580 CHEMBL230411 Bioactive (3E)-3-ethoxyimino-2-[[4-[2-[2-(4-fluorophenyl)-5-methyl-1,3-oxazol-4-yl]ethoxy]phenyl]methyl]butanoic acid
CFAMM00067278 CHEMBL481550 Bioactive (4Z)-4-[6-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]hexoxyimino]-4-phenylbutanoic acid
CFAMM00067665 CHEMBL247660 Bioactive 2-[(1S)-5-[2-[5-ethyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
CFAMM00067319 CHEMBL246205 Bioactive 2-[(1S)-5-[2-[5-methyl-2-(4-propan-2-ylphenyl)-1,3-oxazol-4-yl]ethoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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