CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD458
Family Name Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Family
No. of Seeds 5 No. of Other Members 84
Family Centroid CFAMM00067745 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Prostaglandin G/H synthase 2 Inhibitor Ketoprofen Superfamily
Class Class 368

Cousin Family NamesSeedsMembers
Retinoid X receptor Ligand Bexarotene Family 7 492
Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family 22 503
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
Vitamin K epoxide reductase complex subunit 1 Inhibitor Phenin... 5 44
DNA topoisomerase 2-beta Inhibitor Salvicine Family 2 9
CPI-613 family 4 35
Dihydroorotate dehydrogenase Inhibitor Polyporic Acid Family 4 13
Carbonic anhydrase 2 Inhibitor 4-(hydroxymercury)benzoic Acid ... 7 97
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU79256 F... 1 0
Beta-lactamase Inhibitor 4-carboxyphenylboronic Acid Family 1 1
Cathepsin L1 Inhibitor Biphenyl-4-yl-acetaldehyde Family 2 86
Carboxypeptidase B2 Inhibitor Dl-benzylsuccinic Acid Family 1 11
Cytosolic phospholipase A2 Inhibitor 1,1,1,2,2-pentafluoro-8-p... 11 18
C-X-C chemokine receptor type 1 and C-X-C chemokine receptor t... 2 53
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,5-difluorophenyl)... 12 10
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,3,6-trifluorophen... 16 11
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Glutamate carboxypeptidase 2 Inhibitor 2-(3-carboxybenzyl)succ... 2 7
Glutamate carboxypeptidase 2 Inhibitor 2-(3-cyanobenzyl)-5-mer... 1 0
Glutamate carboxypeptidase 2 Inhibitor 3-(2-carboxy-6-mercapto... 9 4
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 8
Thyroid hormone receptor beta Ligand (4-hexylphenyl)(oxiran-2-... 1 16
Liver carboxylesterase 1 Inhibitor Acenanthrene-9,10-dione Family 2 12
Calcium-activated potassium channel subunit alpha-1 Ligand Tri... 1 10
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-methoxy-1,4-naphthoq... 1 3
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Collagenase 3 and Macrophage metalloelastase Inhibitor 5-(4'-c... 4 43
4-hydroxyphenylpyruvate dioxygenase Inhibitor 2-(2-iodo-benzoy... 3 1
Prostaglandin G/H synthase 1 Inhibitor 2-(3'-ethylsulfanyl-bip... 1 4
Neuraminidase Inhibitor (e,e)-1,7-diphenyl-4,6-heptadien-3-one... 2 5
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 2-[9-... 2 15
Free fatty acid receptor 1 and Free fatty acid receptor 4 liga... 1 7
Thromboxane A2 receptor ligand (Z)-7-[3-[(E,3R,4S)-3-hydroxy-4... 1 7
Chymotrypsinogen B inhibitor (6E)-6-(iodomethylidene)-4-phenyl... 1 1
Glutamate carboxypeptidase 2 inhibitor SureCN5052894 family 1 17
Pol polyprotein inhibitor AGN-PC-0AKRX6 family 1 24
Protease and Pol polyprotein inhibitor U-96988 family 3 15
Arachidonate 15-lipoxygenase inhibitor SureCN9469035 family 6 40
Integrase inhibitor AC1LA8YG family 2 9
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 1 2
Peroxisome proliferator-activated receptor gamma ligand SureCN... 3 3
Retinal dehydrogenase 1 and Microtubule-associated protein tau... 1 7
Thyrotropin receptor and Retinal dehydrogenase 1 ligand NINHYD... 1 1
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 18
Integrase inhibitor AGN-PC-00QHSA family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter inhibitor AGN-PC-074TA8 ... 2 5
Thromboxane A2 receptor ligand (Z)-7-[(4S,5R)-2,2-dimethyl-4-p... 2 9
Microtubule-associated protein tau and Putative fructose-1,6-b... 1 1
Free fatty acid receptor 1 ligand 3-[4-[2-(3-formylphenyl)ethy... 1 0
Squalene synthase inhibitor L-731120 family 2 1
Indanes Metabolite (R)-Pterosin B Family 5 8
Carboxylic Acids and Derivatives Metabolite 3-Acetoxy-3-methyl... 2 0
Putative NP ZINC14410655 Family 6 4
(1S)-1-hydroxy-1,4-dimethyl-2,3-dihydrocyclopenta[b]anthracene... 1 1
Putative NP ZINC55501736 Family 12 4
Putative NP ZINC06763537 Family 6 4
2-methyl-3-oxo-1-phenylcyclopentane-1-carboxylate NP ZINC02496... 4 1
7a-hydroxy-7-phenyl-3,3a,4,5,6,7-hexahydro-1-benzofuran-2-one ... 4 0
carboxylate NP ZINC04026424 Family 3 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00067745 DAP000623 Approved Drug Ketoprofen
CFAMM00067779 DCL000326 Clinical Trial Drug Seratrodast
CFAMM00067820 DNC005410 Investigative Drug R-KETOPROFEN
CFAMM00067769 DNC004614 Investigative Drug 8-Oxo-8-phenyl-octanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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