CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Tumor necrosis factor inhibitor xanthine derivative Pentoxifylline Family
No. of Seeds 5 No. of Other Members 69
Family Centroid CFAMM00008140 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase, TNF inhibitor xanthine derivative Superfamily
Class Class 2

Cousin Family NamesSeedsMembers
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xant... 18 210
xanthine alkaloid Theobromine family 6 10
DNA polymerase inhibitor guanosine analog Aciclovir Family 4 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor xant... 3 7
HIV reverse transcriptase inhibitor guanosine analog Didanosin... 20 166
Adenosine receptor A1 Ligand MK-7418 Family 21 116
UDP-N-acetylglucosamine 1-carboxyvinyltransferase Inhibitor RW... 1 0
Purine nucleoside phosphorylase Inhibitor 9-(5,5-difluoro-5-ph... 1 16
Hypoxanthine-guanine-xanthine phosphoribosyltransferase Inhibi... 3 7
Adenosine receptor A1 Ligand 7-(3,6,9,12-tetraoxatricos-22-eny... 1 1
Purine nucleoside phosphorylase inhibitor [(3R,4S)-3-(2-amino-... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand NSC14... 1 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Adenosine receptor A1 and Adenosine receptor A2b ligand 8-(1-$... 2 2
Dipeptidyl peptidase 4 inhibitor SureCN554974 family 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 1 0


External ID

Functional Category

Molecule Name

CFAMM00008140 DAP000048 Approved Drug Pentoxifylline
CFAMM00008129 DNAP001490 Approved Drug Propentofylline propionate
CFAMM00008162 DNCL002881 Clinical Trial Drug Lisofylline
CFAMM00008131 DNC003764 Investigative Drug DENBUFYLLINE
CFAMM00008199 DNC011865 Investigative Drug 1,3,7-Tripropyl-3,7-dihydro-purine-2,6-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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