CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD466
Family Name Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family
No. of Seeds 4 No. of Other Members 311
Family Centroid CFAMM00068515 Functional Category Approved Drug with Natural Product
Superfamily Peptide deformylase, mitochondrial Inhibitor Trimetrexate Superfamily
Class Class 377

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
MK-6096 family 3 69
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-00EQPZ fa... 3 4
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Glycogen synthase kinase-3 alpha and Casein kinase II subunit ... 1 16
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 4
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxi... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Dihydrofolate reductase inhibitor 2-bromo-N-[4-[4-[(2,4-diamin... 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Adenosine kinase inhibitor SureCN8139139 family 1 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VO0 family 1 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Insulin-like growth factor 1 receptor ligand AGN-PC-044T61 family 1 0
Receptor-type tyrosine-protein kinase FLT3 ligand 1-phenyl-3-N... 2 2
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 2
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Platelet-derived growth factor receptor beta ligand N-(4-chlor... 1 0
C-X-C chemokine receptor type 3 ligand (6aR,9R)-9-N,9-N-diethy... 1 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00068515 DAP000635 Approved Drug Trimetrexate
CFAMM00068538 CHEMBL1760041 Bioactive 4-N-quinolin-6-yl-2-N-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
CFAMM00068477 DNC004816 Investigative Drug GNF-PF-607
CFAMM00068529 DNC003943 Investigative Drug RPR-108518A

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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