CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Thymidylate synthase inhibitor pyrrotopyrimidine derivative Pemetrexed family
No. of Seeds 4 No. of Other Members 23
Family Centroid CFAMM00008218 Functional Category Approved Drug with Human Metabolite
Superfamily Thymidylate synthase inhibitor pyrrotopyrimidine derivative Pemetrexed Superfamily
Class Class 46

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Trifunctional purine biosynthetic protein adenosine-3 and Prot... 3 5
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Thymidylate synthase and Dihydrofolate reductase inhibitor (2S... 1 0


External ID

Functional Category

Molecule Name

CFAMM00008218 DAP000049 Approved Drug Pemetrexed
CFAMM00008230 CHEMBL225072 Bioactive Pemetrexed
CFAMM00008207 DNC003049 Investigative Drug Ly231514 Tetra Glu
CFAMM00008224 DNC003054 Investigative Drug LY341770

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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