CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name DNA topoisomerase 1 Inhibitor Irinotecan Family
No. of Seeds 5 No. of Other Members 29
Family Centroid CFAMM00068887 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily DNA topoisomerase 1 Inhibitor Irinotecan Superfamily
Class Class 97

Cousin Family NamesSeedsMembers
BNP1350 family 8 37
DNA topoisomerase 1 inhibitor AC1LAHQQ family 5 14


External ID

Functional Category

Molecule Name

CFAMM00068887 DAP000647 Approved Drug Irinotecan
CFAMM00068870 DAP001449 Approved Drug Topetecan
CFAMM00068885 DAP000648 Approved Drug Topotecan
CFAMM00068845 DNC001345 Investigative Drug SN-38
CFAMM00068866 DNC000028 Investigative Drug 10-hydroxycamptothecin

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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