CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name DNA topoisomerase 2-beta Inhibitor Etoposide Family
No. of Seeds 3 No. of Other Members 29
Family Centroid CFAMM00069023 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily DNA topoisomerase 2-beta Inhibitor Etoposide Superfamily
Class Class 384

Cousin Family NamesSeedsMembers
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Hidrosmin family 14 61
Chromomycin A3 family 7 14
DNA topoisomerase 2-beta Inhibitor TOP-53 Family 2 12
Transient receptor potential cation channel subfamily V member... 29 18
Endothelin-1 receptor Ligand PD156707 Family 41 211
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor Hinokinin Family 2 10
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Steroids and Steroid Derivatives Metabolite 2-Methoxyestrone 3... 1 3


External ID

Functional Category

Molecule Name

CFAMM00069051 DAP000651 Approved Drug Teniposide
CFAMM00069031 DNAP001346 Approved Drug Epipodophyllotoxin
CFAMM00069023 DAP000786 Approved Drug Etoposide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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