CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD479
Family Name Epidermal growth factor receptor Ligand Gefitinib Family
No. of Seeds 26 No. of Other Members 600
Family Centroid CFAMM00069255 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Epidermal growth factor receptor Ligand Gefitinib Superfamily
Class Class 386

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Aurora kinase B and Aurora kinase A Inhibitor AZD1152 Family 24 11
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Tivozanib family 4 6
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Varlitinib family 2 8
MK-6096 family 3 69
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Melanin-concentrating hormone receptor 1 Ligand ADS-102891 Family 6 51
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Proto-oncogene tyrosine-protein kinase Src inhibitor N-(2,4-di... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Dual specificity mitogen-activated protein kinase kinase 1 inh... 5 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Aurora kinase A inhibitor AGN-PC-00BCUF family 16 43
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Receptor-type tyrosine-protein kinase FLT3 ligand 2-(6,7-dimet... 3 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxi... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Alpha-1A adrenergic receptor ligand 4-[4-(4-amino-6,7-dimethox... 3 0
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Adenosine kinase inhibitor SureCN8134468 family 3 7
Vascular endothelial growth factor receptor 2 and Vascular end... 3 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Methionine--tRNA ligase inhibitor SureCN7818675 family 7 14
Methionine--tRNA ligase inhibitor 2-[3-[(3-bromo-2-ethoxy-5-me... 2 1
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Equilibrative nucleoside transporter 1 inhibitor SureCN9046933... 2 9
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 3 21
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 3 1
Dihydrofolate reductase inhibitor 2-bromo-N-[4-[4-[(2,4-diamin... 1 0
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Fatty-acid amide hydrolase 1 inhibitor (1R)-2-[[6-(3-chloro-4-... 1 4
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FPC ... 6 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Platelet-derived growth factor receptor beta ligand AGN-PC-075... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Vascular endothelial growth factor receptor 3 and Platelet-der... 8 13
Platelet-derived growth factor receptor beta and Receptor-type... 6 5
Platelet-derived growth factor receptor beta and Receptor-type... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Receptor tyrosine-protein kinase erbB-2 and Tyrosine-protein k... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Platelet-derived growth factor receptor alpha and Mast/stem ce... 2 2
Platelet-derived growth factor receptor beta and Mast/stem cel... 1 0
Protein-tyrosine kinase 2-beta and Focal adhesion kinase 1 inh... 3 6
Hepatocyte growth factor receptor and Vascular endothelial gro... 15 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Aurora kinase A inhibitor AGN-PC-0760BB family 1 1
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Aurora kinase A inhibitor SureCN4289024 family 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
TRAF2 and NCK-interacting protein kinase inhibitor 4-methoxy-3... 4 1
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 4 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Hepatocyte growth factor receptor ligand 1-[(E)-(2,4-difluorop... 2 0
Deoxycytidine kinase inhibitor 2-[5-[4-[(4,6-diaminopyrimidin-... 14 11
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-1-N-(4... 3 9
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Receptor tyrosine-protein kinase erbB-2 ligand SureCN3374869 f... 4 8
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[(5-fl... 3 2
Transient receptor potential cation channel subfamily V member... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 and Tyrosine-pro... 4 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
Adenosine kinase inhibitor SureCN8139139 family 1 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Cathepsin S and Cathepsin L1 inhibitor AGN-PC-077QOL family 1 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Vascular endothelial growth factor receptor 2 ligand pyrimidin... 2 2
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 9 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 4 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Ephrin type-B receptor 4 ligand AGN-PC-077MSC family 4 15
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 10 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 7
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Adenosine receptor A1 ligand BAS 00727702 family 1 4
Inositol monophosphatase 1 and Prelamin-A/C inhibitor GNF-Pf-3... 1 5
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Tyrosine-protein kinase receptor Tie-1 and Receptor-type tyros... 1 0
Epidermal growth factor receptor ligand AGN-PC-07B1XF family 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
cGMP-specific 3',5'-cyclic phosphodiesterase and cAMP-specific... 1 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Insulin-like growth factor 1 receptor ligand AGN-PC-044T61 family 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 2 10
Serine/threonine-protein kinase ATR inhibitor 4-[2-(6-methoxy-... 1 0
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Nitric oxide synthase, inducible inhibitor SureCN6943121 family 6 4
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-[(... 1 0
Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-073... 1 1
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Glucokinase inhibitor AGN-PC-03ZE4O family 4 5
Vascular endothelial growth factor receptor 2 and Serine/threo... 4 2
Vascular endothelial growth factor receptor 1 and Vascular end... 1 1
Platelet-derived growth factor receptor beta ligand N-(4-chlor... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0
Platelet-derived growth factor receptor beta ligand SureCN2919... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00069249 DAP001010 Approved Drug Erlotinib
CFAMM00069255 DAP000657 Approved Drug Gefitinib
CFAMM00069572 CHEMBL94431 Bioactive 11N-112
CFAMM00069374 CHEMBL1203935 Bioactive 6,7-diethoxy-N-[3-fluoro-5-(trifluoromethyl)phenyl]quinazolin-4-amine;hydrochloride
CFAMM00069797 CHEMBL50084 Bioactive AGN-PC-00OA8G
CFAMM00069414 CHEMBL147393 Bioactive AGN-PC-0005IM
CFAMM00069263 CHEMBL541586 Bioactive SureCN5475745
CFAMM00069139 CHEMBL51056 Bioactive AGN-PC-00OA8K
CFAMM00069372 CHEMBL1203939 Bioactive 6,7-diethoxy-N-(2-fluorophenyl)quinazolin-4-amine;hydrochloride
CFAMM00069313 CHEMBL516979 Bioactive (7R,8R)-N-(3-iodophenyl)-7,8-bis(methoxymethyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine
CFAMM00069499 CHEMBL1204261 Bioactive 6,7-diethoxy-N-(3-fluorophenyl)quinazolin-4-amine;hydrochloride
CFAMM00069268 CHEMBL54288 Bioactive AGN-PC-00OA8L
CFAMM00069161 CHEMBL339685 Bioactive SureCN13330456
CFAMM00069810 CHEMBL8603 Bioactive 2-[4-(4-ethoxypyrimidin-2-yl)piperazin-1-yl]-6,7-dimethoxyquinolin-4-amine
CFAMM00069317 CHEMBL125717 Bioactive 4-[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]-N-(4-phenoxyphenyl)piperazine-1-carboxamide
CFAMM00069489 CHEMBL102911 Bioactive SureCN2921098
CFAMM00069254 DCL000367 Clinical Trial Drug Tandutinib
CFAMM00069280 DCL000020 Clinical Trial Drug CPG 52364
CFAMM00069181 DCL000350 Clinical Trial Drug Vandetanib
CFAMM00069669 DNC004486 Investigative Drug RPR-108514A
CFAMM00069399 DNC000473 Investigative Drug CP-358774
CFAMM00069383 DNC002911 Investigative Drug 4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline
CFAMM00069544 DNC009020 Investigative Drug 6,7-dimethoxy-N-m-tolylquinazolin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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