CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD49
Family Name Serotonin re-uptake inhibitor tetralin derivative Sertraline family
No. of Seeds 12 No. of Other Members 118
Family Centroid CFAMM00008383 Functional Category Approved Drug
Superfamily Monoamine reuptake inhibitor Sertraline Sibutramine Superfamily
Class Class 48

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Dopamine reuptake and Noradrenergic re-uptake Inhibitor Dov 21... 16 89
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Zicronapine family 43 62
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 6 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 9 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 3 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 2-[4... 1 0
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sigma non-opioid intracellular receptor 1 ligand NCI60_039912 ... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00008383 DAP000051 Approved Drug Sertraline
CFAMM00008469 CHEMBL356552 Bioactive (1S,3S)-3-(3,4-dichlorophenyl)-N-ethyl-2,3-dihydro-1H-inden-1-amine
CFAMM00008445 CHEMBL544971 Bioactive AGN-PC-07BYWY
CFAMM00008490 CHEMBL146332 Bioactive SureCN585770
CFAMM00008431 CHEMBL545201 Bioactive AGN-PC-07BYX2
CFAMM00008475 CHEMBL284994 Bioactive rac-trans-Sertraline
CFAMM00008368 CHEMBL544266 Bioactive (+)-trans-3-(3,,4-dichlorophenyl)-N-methyl-1-indanamine hydrochloride
CFAMM00008443 CHEMBL553590 Bioactive AGN-PC-00MZRS
CFAMM00008465 CHEMBL147983 Bioactive (1R,3S)-3-(3,4-dichlorophenyl)-N-ethyl-2,3-dihydro-1H-inden-1-amine
CFAMM00008420 DNC000206 Investigative Drug Aminopurvalanol (NG97)
CFAMM00008380 DNC000795 Investigative Drug Indatraline
CFAMM00008432 DNC012726 Investigative Drug [3-(3,4-Dichloro-phenyl)-indan-1-yl]-methyl-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21768 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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