CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD5
Family Name Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline derivative Sunitinib Family
No. of Seeds 4 No. of Other Members 151
Family Centroid CFAMM00000585 Functional Category Approved Drug with Natural Product
Superfamily Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline derivative Sunitinib Superfamily
Class Class 5

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 16 0
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibi... 2 5
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Substance-K receptor ligand 1-N,2-N-bis[2-(1H-indol-3-yl)ethyl... 1 0
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Translocator protein inhibitor AGN-PC-07RE6S family 1 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Serine/threonine-protein kinase pim-3 and Serine/threonine-pro... 4 6
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase inhibitor SureCN57283... 2 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Motilin receptor ligand SureCN2768052 family 3 0
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 3 3
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Platelet-derived growth factor receptor beta and Vascular endo... 1 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Kinesin-like protein KIF11 inhibitor 9-(trifluoromethyl)-1,2,4... 4 1
Vascular endothelial growth factor receptor 2 ligand 3-[2-[(Z)... 1 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Histone deacetylase 1 inhibitor N-[(2S)-1,8-dioxo-1-[2-(2-phen... 2 0
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00000585 DAP000005 Approved Drug Sunitinib
CFAMM00000538 DCL000646 Clinical Trial Drug Sunitinib malate
CFAMM00000530 DCL000629 Clinical Trial Drug Romiplostim
CFAMM00000455 DCL000357 Clinical Trial Drug SU-14813

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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