CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Noradrenergic re-uptake and Serotonin re-uptake inhibitor phenethylamine derivative Bupropion family
No. of Seeds 18 No. of Other Members 41
Family Centroid CFAMM00008523 Functional Category Approved Drug with Human Metabolite
Superfamily Monoamine reuptake, metabotropic transmembrane receptor binder amphetamine Progabide Superfamily
Class Class 49

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Chymase Inhibitor Phenylalanylmethane Family 1 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 1
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Sigma non-opioid intracellular receptor 1 ligand N-Phprop-clph... 1 12
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0


External ID

Functional Category

Molecule Name

CFAMM00008523 DAP000052 Approved Drug Bupropion
CFAMM00008531 CHEMBL565844 Bioactive SureCN770607
CFAMM00008550 CHEMBL578612 Bioactive SureCN770030
CFAMM00008549 CHEMBL578611 Bioactive SureCN633943
CFAMM00008507 CHEMBL567481 Bioactive AGN-PC-077DJU
CFAMM00008545 DCL000947 Clinical Trial Drug Radafaxine
CFAMM00008558 DNC010127 Investigative Drug 2-(tert-Butylamino)-3',4'-dichloropentanophenone
CFAMM00008514 DNC010121 Investigative Drug 2-(tert-Butylamino)-3',4'-dichlorobutyrophenone
CFAMM00008496 DNC010131 Investigative Drug 2-(tert-butylamino)-1-(3-chlorophenyl)butan-1-one
CFAMM00008513 DNC010123 Investigative Drug 2-(N-Cyclopentylamino)-3'-chloropropiophenone
CFAMM00008541 DNC010115 Investigative Drug 2-(N-Cyclopropylamino)-3-chloropropiophenone
CFAMM00008512 DNC010125 Investigative Drug 2-(N-Isopropylamino)-3'-chloropropiophenone
CFAMM00008540 DNC010117 Investigative Drug 2-(N-tert-Butylamino)-3'-chlorooctanophenone
CFAMM00008500 DNC010124 Investigative Drug 2-(N-tert-Butylamino)-3',4'-dichloropropiophenone
CFAMM00008537 DNC010119 Investigative Drug 2-(N-tert-Butylamino)-4'-chloropropiophenone
CFAMM00008509 DNC010126 Investigative Drug 2-(N-tert-Butylamino)-3'-chloroheptanophenone
CFAMM00008498 DNC010133 Investigative Drug 2-(N-tert-Butylamino)-3'-chlorohexanophenone
CFAMM00008516 DNC010129 Investigative Drug 2-(N-tert-Butylamino)-3'-chloropentanophenone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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