CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD506
Family Name Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family
No. of Seeds 4 No. of Other Members 173
Family Centroid CFAMM00071001 Functional Category Approved Drug with Natural Product
Superfamily Glycoprotein IIb/IIIa receptor Ligand Tirofiban Superfamily
Class Class 406

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Oxytocin receptor Ligand Oxytocin Family 30 182
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
HIV-1 protease Inhibitor Lopinavir Family 4 25
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Renin Inhibitor Aliskiren Family 28 107
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Zucapsacin family 7 177
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Plitidepsin family 15 5
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Vasopeptidase Inhibitor Fasidotril Family 3 7
Neprilysin Inhibitor Thiorphan Family 41 68
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F and Cruzipain Inhibitor Benzoyl-arginine-alanine-m... 49 348
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Integrin beta-3 Inhibitor FK-633 Family 2 12
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-tyr(me)-agly-i... 2 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Caspase-1 Inhibitor Z-vad-cho Family 8 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Pol polyprotein inhibitor 180968-31-4 family 8 13
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 8 12
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 5 4
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 2 2
Neprilysin and Aminopeptidase N inhibitor benzyl 2-[[(2S)-2-[[... 1 1
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Caspase-3 and Caspase-1 inhibitor (3S)-3-[[(2S)-3-methyl-2-[(2... 1 3
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 4 10
Serine palmitoyltransferase 1 and Serine palmitoyltransferase ... 2 1
Transient receptor potential cation channel subfamily V member... 3 18
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Neprilysin inhibitor SureCN389939 family 5 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-(ben... 12 20
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6453971 f... 3 4
Pol polyprotein inhibitor AC1LADQG family 7 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Histamine H3 receptor ligand SureCN5093910 family 3 16
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 16 23
Collagenase 3 and A disintegrin and metalloproteinase with thr... 10 19
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 3 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Integrin beta-3 and Integrin alpha-IIb inhibitor (2S)-5-(diami... 2 0
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
72 kDa type IV collagenase and Neutrophil collagenase inhibito... 12 20
Caspase-1 inhibitor (3S)-3-[2-[3-(naphthalene-1-carbonylamino)... 13 5
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor 2-[(3Z)... 4 3
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Tryptase alpha/beta-1 and Tryptase delta inhibitor (2S,3R)-4-o... 4 5
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic receptor M... 2 2
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
Renin inhibitor ethyl N-[1-[[1-[[(2S,3R,4S)-1-cyclohexyl-3,4-d... 2 0
Collagenase 3 inhibitor (2R)-2-[[5-(4-ethoxyphenyl)thiophen-2-... 34 1
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 9
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 2 1
Angiotensin-converting enzyme inhibitor (2S,4S)-1-[(2S)-2-meth... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 2 0
Stromelysin-1 inhibitor (2R)-2-[[(2S)-1-[(6S)-6-(methylcarbamo... 1 1
Metabotropic glutamate receptor 1 ligand methyl (2R)-2-[[(1aR,... 2 0
N-acylethanolamine-hydrolyzing acid amidase inhibitor (4-pheny... 1 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Pol polyprotein inhibitor AC1MHYEO family 1 0
Tyrosine-protein phosphatase non-receptor type 2 and Tyrosine-... 6 0
N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(4-methoxyphenyl)te... 2 0
2-[4-(6-methoxy-2-oxochromen-3-yl)phenoxy]acetamide NP (s)-n-(... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00071001 DAP000696 Approved Drug Tirofiban
CFAMM00071058 CHEMBL254911 Bioactive (2S)-3-[4-[(4-fluorophenyl)methoxy]phenyl]-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]propanoic acid
CFAMM00071042 CHEMBL254282 Bioactive (2S)-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]-3-(4-phenoxyphenyl)propanoic acid
CFAMM00071034 CHEMBL254703 Bioactive (2S)-2-[[(2S,3R)-3-methyl-2-sulfanylpentanoyl]amino]-3-(4-phenylmethoxyphenyl)propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26397 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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