CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Histamine N-methyltransferase inhibitor aminoquinoline Amodiaquine Family
No. of Seeds 8 No. of Other Members 23
Family Centroid CFAMM00071330 Functional Category Approved Drug
Superfamily Histamine N-methyltransferase inhibitor aminoquinoline Amodiaquine Phospholipase A2 inhibitor Quinacrine Superfamily
Class Class 409

Cousin Family NamesSeedsMembers
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
Glucocorticoid receptor ligand 4-fluoro-2-[5,5,5-trifluoro-4-h... 3 9
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 30
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 15
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 5 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 0
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Androgen receptor ligand (6R,7S)-6-ethyl-7-methyl-4-(trifluoro... 22 29
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN4... 9 2
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
Histidine-rich protein PFHRP-II inhibitor AGN-PC-075SYG family 1 0


External ID

Functional Category

Molecule Name

CFAMM00071330 DAP000699 Approved Drug Amodiaquine
CFAMM00071315 CHEMBL2147459 Bioactive 2-[[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonylamino]methyl]phenol
CFAMM00071321 CHEMBL2147361 Bioactive 2-[[2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethylamino]methyl]phenol
CFAMM00071318 CHEMBL2147456 Bioactive 2-[[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octylamino]methyl]phenol
CFAMM00071322 DNC009047 Investigative Drug desethyl isoquine
CFAMM00071323 DNC009046 Investigative Drug GSK-369796
CFAMM00071345 DNC008784 Investigative Drug ISOQUINE
CFAMM00071344 DNC008785 Investigative Drug DESETHYL AMODIAQUINE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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