CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name HIV reverse transcriptase inhibitor guanosine analog Didanosine Family
No. of Seeds 20 No. of Other Members 166
Family Centroid CFAMM00071473 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily DNA polymerase inhibitor guanosine analog Aciclovir Didanosine Superfamily
Class Class 283

Cousin Family NamesSeedsMembers
Tumor necrosis factor inhibitor xanthine derivative Pentoxifyl... 5 69
Adenosine receptor A3 ligand purine nucleoside Adenosine Family 47 847
DNA polymerase inhibitor guanosine analog Aciclovir Family 4 41
Adenosine deaminase Inhibitor Pentostatin Family 4 13
DNA polymerase Inhibitor Valaciclovir Family 2 0
Inosine-5'-monophosphate dehydrogenase Inhibitor Mizoribine Fa... 1 0
Poly-iclc family 1 0
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Selenazole-... 2 1
Reverse transcriptase/RNaseH inhibitor 9-[(2R,3R,4R,5R)-4-[hyd... 1 0
NS3 inhibitor sodium;[[[(2S,3R,4S,5S)-5-(4,8-diamino-6-iminoim... 1 0
Reverse transcriptase/RNaseH inhibitor [(2R,3R,4R,5R)-4-methox... 1 0
Carbohydrates and Carbohydrate Conjugates Metabolite 6-Thioxan... 1 0


External ID

Functional Category

Molecule Name

CFAMM00071473 DAP000702 Approved Drug Didanosine
CFAMM00071376 CHEMBL1627119 Bioactive tetralithium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
CFAMM00071367 DCL001214 Clinical Trial Drug MIV-210
CFAMM00071450 DCL000136 Clinical Trial Drug INO-1001
CFAMM00071570 DNC003186 Investigative Drug Cyclic Guanosine Monophosphate
CFAMM00071490 DNC000666 Investigative Drug G-25
CFAMM00071475 DNC014828 Investigative Drug alpha,beta-methylene-dGTP
CFAMM00071489 DNC002559 Investigative Drug 3-Deoxyguanosine
CFAMM00071496 DNC002557 Investigative Drug Guanosine
CFAMM00071423 DNC002864 Investigative Drug Guanosine-5'-Diphosphate
CFAMM00071371 DNC003163 Investigative Drug Phosphomethylphosphonic Acid Guanylate Ester
CFAMM00071494 DNC002554 Investigative Drug 2'3'-Dideoxyinosine
CFAMM00071370 DNC003162 Investigative Drug Guanosine-5',3'-Tetraphosphate
CFAMM00071493 DNC000107 Investigative Drug 8-aminoguanosine
CFAMM00071557 DNC013652 Investigative Drug FAICAR
CFAMM00071443 DNC002715 Investigative Drug Inosinic Acid
CFAMM00071556 DNC002535 Investigative Drug Guanosine-5'-Triphosphate
CFAMM00071385 DNC003278 Investigative Drug 5'-Guanosine-Diphosphate-Monothiophosphate
CFAMM00071499 DNC003058 Investigative Drug 2'-Deoxyguanosine-5'-Monophosphate
CFAMM00071442 DNC003422 Investigative Drug 7-Methyl-Guanosine-5'-Triphosphate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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