CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name HIV-1 protease Inhibitor Nelfinavir Family
No. of Seeds 11 No. of Other Members 26
Family Centroid CFAMM00071600 Functional Category Approved Drug
Superfamily HIV-1 protease Inhibitor Nelfinavir Superfamily
Class Class 411

Cousin Family NamesSeedsMembers
Plasmepsin-2 Inhibitor KNI-10314 Family 6 2
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Pol polyprotein inhibitor AHPBA 33 family 2 6
Pol polyprotein inhibitor AHPBA deriv. 33 family 13 0
Pol polyprotein inhibitor KNI-1279 family 3 0
Beta-secretase 1 and Cathepsin B inhibitor N-[(2S)-1-[[(2S,3R)... 2 1
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Pol polyprotein inhibitor AC1LA3AI family 5 9
Pol polyprotein inhibitor 168912-67-2 family 1 0
Pol polyprotein inhibitor AHPBA 25 family 2 2
Pol polyprotein inhibitor AC1L9U3V family 1 0


External ID

Functional Category

Molecule Name

CFAMM00071600 DAP000705 Approved Drug Nelfinavir
CFAMM00071632 CHEMBL300257 Bioactive AC1LAQ7R
CFAMM00071616 CHEMBL98710 Bioactive AC1LA3W3
CFAMM00071631 CHEMBL54191 Bioactive JE-533
CFAMM00071609 CHEMBL1159655 Bioactive NELFINAVIR
CFAMM00071615 CHEMBL98096 Bioactive (3aR,6S,7aS)-N-tert-butyl-5-[(2R,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutyl]-3,3a,4,6,7,7a-hexahydro-2H-thieno[3,2-c]pyridine-6-carboxamide
CFAMM00071621 CHEMBL443790 Bioactive AC1LAQ8R
CFAMM00071635 CHEMBL1205 Bioactive Nelfinavir mesylate
CFAMM00071619 CHEMBL432887 Bioactive AC1LAQ8I
CFAMM00071605 CHEMBL299198 Bioactive JE-1520
CFAMM00071610 DNC009934 Investigative Drug KNI-764

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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