CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD515
Family Name HIV-1 protease Inhibitor Lopinavir Family
No. of Seeds 4 No. of Other Members 25
Family Centroid CFAMM00071717 Functional Category Approved Drug
Superfamily HIV-1 protease Inhibitor Lopinavir Superfamily
Class Class 412

Cousin Family NamesSeedsMembers
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Plitidepsin family 15 5
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Histamine H3 receptor Ligand A-349821 Family 49 228
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Plasmepsin-2 Inhibitor KNI-10079 Family 19 8
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 5 2
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-5-benzyl-3-... 2 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Pol polyprotein inhibitor benzyl N-[(2S)-1-[[(2S,3S,4R,5S)-3,4... 21 5
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Pol polyprotein inhibitor MDL 74538 family 11 1
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 4 3
Beta-secretase 1 and Cathepsin D inhibitor N-[(2S,3R)-1-(3,5-d... 10 15
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Motilin receptor ligand SureCN74051 family 1 0
Renin inhibitor (3S,6R)-6-(cyclohexylmethyl)-7-hydroxy-7-[[(2S... 1 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 2 0
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Pol polyprotein inhibitor AC1LALH8 family 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN76477... 2 1
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Renin inhibitor N-[2-[[(2R)-1-[[(2S,3R,4S)-3,4-dihydroxy-6-met... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00071717 DAP000708 Approved Drug Lopinavir
CFAMM00071748 CHEMBL30207 Bioactive Lopinavir Metabolite M-3/M-4
CFAMM00071741 CHEMBL30185 Bioactive Lopinavir Metabolite M-1
CFAMM00071737 CHEMBL12900 Bioactive AC1L9X2B

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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