CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD517
Family Name Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitracin Family
No. of Seeds 30 No. of Other Members 259
Family Centroid CFAMM00071905 Functional Category Approved Drug with Human Metabolite
Superfamily Insulin-degrading enzyme inhibitor Bacitracin, Renin inhibitor Remikiren Superfamily
Class Class 414

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Epidermal Growth Factor family 111 209
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Insulin receptor Ligand Insulin, Porcine Family 61 205
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Renin Inhibitor Remikiren Family 100 126
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Growth hormone receptor Ligand EP-51216 Family 34 390
NS5A protein Inhibitor Bms 790052 Family 5 9
CBP-501 family 7 8
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Renin Inhibitor Enalkiren Family 56 44
Caspase-9 Inhibitor Z-lehd-fmk Family 1 0
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Glycylpeptide N-tetradecanoyltransferase Inhibitor SC-58272 Fa... 2 11
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Pol polyprotein inhibitor penicillin deriv. 71 family 1 2
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Glucagon-like peptide 1 receptor ligand CHEMBL1092373 family 5 2
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Pol polyprotein inhibitor AC1LA3L0 family 3 2
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 1 1
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Placenta growth factor inhibitor CHEMBL1689479 family 4 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN9... 3 10
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand CHE... 1 0
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Melanocortin receptor 4 ligand CHEMBL2415084 family 3 0
Renin inhibitor (4S)-5-cyclohexyl-2,2-difluoro-4-[[(2S)-3-(1H-... 1 0
Gastrin-releasing peptide receptor ligand (2S)-N-[(2S)-1-[[(2S... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-(3-imidazo... 1 0
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Renin inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cyclohexyl-3-hydr... 1 0
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Neuropeptide Y receptor type 2 ligand CHEMBL411765 family 1 0
Epidermal growth factor receptor ligand CHEMBL437469 family 1 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Growth hormone secretagogue receptor type 1 ligand CHEMBL52599... 1 0
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16g... 1 0
Glucagon receptor ligand CHEMBL267876 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00071905 DAP000710 Approved Drug Bacitracin
CFAMM00071858 DAP001296 Approved Drug Secretin
CFAMM00071874 CHEMBL412565 Bioactive CHEMBL412565
CFAMM00071841 CHEMBL2370927 Bioactive CHEMBL2370927
CFAMM00072017 CHEMBL410108 Bioactive CHEMBL410108
CFAMM00072009 CHEMBL2370930 Bioactive CHEMBL2370930
CFAMM00071847 CHEMBL1794009 Bioactive CHEMBL1794009
CFAMM00071919 CHEMBL412799 Bioactive CHEMBL412799
CFAMM00072036 CHEMBL263451 Bioactive CHEMBL263451
CFAMM00071814 CHEMBL2368116 Bioactive CHEMBL2368116
CFAMM00071945 CHEMBL510801 Bioactive hemopressin
CFAMM00071938 CHEMBL2370926 Bioactive CHEMBL2370926
CFAMM00072008 CHEMBL2370933 Bioactive CHEMBL2370933
CFAMM00072035 CHEMBL263544 Bioactive (4S)-4-[[(2R)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-hydroxypropanoyl]amino]-3-octanoyloxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1,5-diamino-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
CFAMM00071897 CHEMBL2370918 Bioactive astressin B
CFAMM00071792 CHEMBL1643388 Bioactive Natriuretic peptide, brain
CFAMM00071936 CHEMBL2370929 Bioactive CHEMBL2370929
CFAMM00071993 CHEMBL427807 Bioactive Urocortin-human
CFAMM00071922 CHEMBL1794010 Bioactive CHEMBL1794010
CFAMM00071863 CHEMBL2370940 Bioactive CHEMBL2370940
CFAMM00071889 CHEMBL526149 Bioactive CHEMBL526149
CFAMM00072005 CHEMBL2370938 Bioactive CHEMBL2370938
CFAMM00071894 CHEMBL2370917 Bioactive CHEMBL2370917
CFAMM00071907 CHEMBL1255581 Bioactive Secretin
CFAMM00072010 CHEMBL2370931 Bioactive CHEMBL2370931
CFAMM00071790 DNC009007 Investigative Drug hCGRPalpha

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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