CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD531
Family Name Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family
No. of Seeds 3 No. of Other Members 39
Family Centroid CFAMM00072659 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Prostaglandin G/H synthase inhibitor salicylates and derivatives Superfamily
Class Class 121

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Ipriflavone family 62 2480
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Mitogen-activated protein kinase 12 Inhibitor SCIO-469 Family 1 7
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Indoleamine 2,3-dioxygenase 1 Inhibitor Garveatin E Family 2 0
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-622444 Family 2 18
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-54162 Family 1 3
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Nuclear receptor ROR-gamma and Huntingtin ligand CHEMBL1568747... 1 3
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
Benzoic Acid and Derivatives Metabolite 5-Sulfosalicylic acid ... 1 2
Benzopyrans Metabolite (-)-trans-3,4-Dihydro-4,8-dihydroxy-3-m... 1 0
Benzofurans Metabolite 4-Hydroxyphthalide Family 1 1
Putative NP ZINC49600254 Family 8 2
2-[(E)-3-hydroxy-3-(6-methyl-2,4-dioxopyran-3-ylidene)prop-1-e... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00072659 DAP000731 Approved Drug Salicyclic acid
CFAMM00072664 DNAP001560 Approved Drug Fosfosal
CFAMM00072670 DNC002522 Investigative Drug 2-HYDROXY-3,5-DIIODOBENZOIC ACID

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27634 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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