CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD535
Family Name Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family
No. of Seeds 4 No. of Other Members 267
Family Centroid CFAMM00073286 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Prostaglandin G/H synthase 2 Inhibitor Nabumetone Superfamily
Class Class 98

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Histamine H1 receptor Ligand Doxepin Family 8 89
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor Ligand Mestranol Family 2 29
Sodium channel Ligand Permethrin Family 1 25
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
Peroxisome proliferator-activated receptor alpha Ligand Ciprof... 1 5
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
TS-071 family 8 36
Eprotirome family 11 50
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Endothelin-1 receptor Ligand PD156707 Family 41 211
Prostaglandin G/H synthase 1 Inhibitor (3-chloro-4-propoxy-phe... 2 10
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 2 14
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Thyroid hormone receptor beta Ligand (3,5-dibromo-4-pentyloxy-... 5 21
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Prostaglandin D2 receptor 2 Ligand 2-(4-cyano-2-cyclohexylphen... 6 3
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Aromatase Inhibitor NSC-122427 Family 1 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
NF-kappa-B Inhibitor Rocaglamide Family 8 8
Tyrosine-protein phosphatase non-receptor type 1 Ligand Formyl... 1 1
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Arachidonate 5-lipoxygenase Inhibitor 4,5-dimethoxy-10h-anthra... 1 4
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Creatine kinase Inhibitor 5-(4'-benzoylbiphenyl-4-yl)-2-furoic... 2 66
Hormone-sensitive lipase Inhibitor 2-(3-methoxybenzylthio)-2-p... 1 19
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Prostaglandin E2 receptor EP3 subtype and D(2) dopamine recept... 2 24
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Melatonin receptor type 1A ligand N-[(7-methoxynaphthalen-1-yl... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 4
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 11
Acetylcholinesterase inhibitor AGN-PC-003A5N family 3 9
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 3
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Free fatty acid receptor 1 ligand 3-[4-[[3-[2,6-dimethyl-4-[3-... 1 0
Free fatty acid receptor 1 ligand 3-[4-[[3-[4-(1,1-dioxothian-... 3 0
Arachidonate 5-lipoxygenase inhibitor methyl (2S)-2-[3-fluoro-... 2 0
Peroxisome proliferator-activated receptor delta and Peroxisom... 4 2
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Kinesin-like protein KIF11 inhibitor 2-amino-5-(4-methoxypheny... 1 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Cysteinyl leukotriene receptor 1 ligand 4-[(E)-1-carboxy-6-[4-... 2 9
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 0
Sterol 26-hydroxylase, mitochondrial and 1,25-dihydroxyvitamin... 1 2
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Free fatty acid receptor 1 ligand 3-[4-[2-[3-(trifluoromethoxy... 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 1
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
Acetylcholinesterase inhibitor SureCN10041451 family 1 1
Thioredoxin glutathione reductase and Beta-lactamase inhibitor... 1 0
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-13-methyl-17-oxo-7... 1 9
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
NS5B protein inhibitor SureCN3988565 family 2 4
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Vasopressin V2 receptor and C-C chemokine receptor type 4 liga... 1 1
Aromatase inhibitor AGN-PC-075LLF family 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00OPWJ family 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 2 and Corticoster... 1 2
Arachidonate 5-lipoxygenase inhibitor AGN-PC-02TTXV family 1 0
Acenes Metabolite Lacinilene C Family 2 3
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Acenes Metabolite 3-Hydroxy-9-(4-hydroxyphenyl)-1H,3H-naphtho[... 1 0
Acenes Metabolite Musanolone D Family 2 1
Naphthofurans Metabolite Pyrocurzerenone Family 1 9
Putative NP ZINC31158464 Family 3 5
Putative NP ZINC04043753 Family 8 6
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0
2-[(3,4-dimethoxyphenyl)methyl]propanedioate NP 4aji Family 1 0
5-(4-methoxyphenyl)-2,2-dimethyloxolan-3-one NP 5-(4-methoxyph... 2 0
NP 4-(5-fluoro-3-methylbenzofuran-2-yl)-7,8-dihydrocyclopenta[... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00073286 DAP000735 Approved Drug Nabumetone
CFAMM00073139 DAP000968 Approved Drug Naproxen
CFAMM00073242 CHEMBL1688488 Bioactive AGN-PC-093LAP
CFAMM00073260 DNC000514 Investigative Drug Daio-Orengedokuto (DOT)

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26851 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543