CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD538
Family Name Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family
No. of Seeds 2 No. of Other Members 99
Family Centroid CFAMM00073528 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Superfamily
Class Class 429

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Motilin receptor and Cytochrome P450 2D6 ligand 7-[[6-(4-chlor... 2 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-07ZA0N family 1 3
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Thromboxane-A synthase inhibitor 4-chloro-N-[8-pyridin-3-yl-5-... 1 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 13 1
5-hydroxytryptamine receptor 2A ligand SureCN5215979 family 2 10
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 8 6
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-(4-... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Prostaglandin D2 receptor 2 ligand 2-[5-fluoro-2-methyl-3-[(4-... 3 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-00CRVW family 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Presenilin-1 and Presenilin-2 inhibitor AGN-PC-050UV6 family 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 4 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Prostaglandin G/H synthase 2 inhibitor 1-(3,4-difluorophenyl)-... 1 3
Glucocorticoid receptor ligand 1-[(4aS)-6-(4-tert-butylphenyl)... 27 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Metabotropic glutamate receptor 5 and Cytochrome P450 1A2 liga... 2 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 0
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00073528 DAP000738 Approved Drug Etoricoxib
CFAMM00073531 DNC014444 Investigative Drug 2-(4-(methylsulfonyl)phenyl)pyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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