CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD543
Family Name Solute carrier family 12 member 1 Inhibitor Torasemide Family
No. of Seeds 13 No. of Other Members 75
Family Centroid CFAMM00073883 Functional Category Approved Drug with Human Metabolite
Superfamily Solute carrier Superfamily 5
Class Class 433

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
Amg 423 family 7 47
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Thromboxane-A synthase Inhibitor CGS-22652 Family 37 95
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 2 9
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 22
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(met... 4 15
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 19 53
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Thyrotropin receptor and Huntingtin ligand CHEMBL1333081 family 1 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Nicotinamide phosphoribosyltransferase and Prelamin-A/C inhibi... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BGV ... 1 0
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-(4-... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Pol polyprotein inhibitor Lysine Sulfonamide 6h family 1 1
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Nicotinamide phosphoribosyltransferase inhibitor 1-[4-(8-oxa-3... 5 4
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Nicotinamide phosphoribosyltransferase inhibitor 1-[4-(1-methy... 1 4
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3,5-di... 4 8
Nicotinamide phosphoribosyltransferase inhibitor 2-[[4-(3-chlo... 1 0
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Neuropeptide Y receptor type 5 ligand AGN-PC-07CNLC family 1 1
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Bombesin receptor subtype-3 ligand 1-tert-butyl-3-[4-[[(1R,3R,... 3 1
Rho-associated protein kinase 2 and Rho-associated protein kin... 1 0
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 0
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 1 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[4-(... 3 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00073883 DAP000745 Approved Drug Torasemide
CFAMM00073936 CHEMBL2391565 Bioactive 1-[4-(4-methylpiperidin-1-yl)sulfonylphenyl]-3-(pyridin-3-ylmethyl)urea
CFAMM00073907 CHEMBL2393171 Bioactive 1-[4-[(4-aminocyclohexyl)sulfamoyl]phenyl]-3-(pyridin-3-ylmethyl)urea
CFAMM00073948 CHEMBL2393168 Bioactive 1-(pyridin-3-ylmethyl)-3-[4-[[5-(trifluoromethyl)-1,4-diazepan-1-yl]sulfonyl]phenyl]urea
CFAMM00073900 CHEMBL2391557 Bioactive 1-[4-(azepan-1-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea
CFAMM00073935 CHEMBL2391564 Bioactive 1-[4-(3-methylpiperidin-1-yl)sulfonylphenyl]-3-(pyridin-3-ylmethyl)urea
CFAMM00073892 CHEMBL1165061 Bioactive AGN-PC-07XZJK
CFAMM00073923 CHEMBL2391570 Bioactive 1-(4-piperidin-1-ylsulfonylphenyl)-3-(pyridin-3-ylmethyl)urea
CFAMM00073932 CHEMBL2391560 Bioactive 1-[4-(butylsulfamoyl)phenyl]-3-(pyridin-3-ylmethyl)urea
CFAMM00073951 CHEMBL2393163 Bioactive 1-[4-(2,8-diazaspiro[4.5]decan-8-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea
CFAMM00073896 CHEMBL2391553 Bioactive 1-(4-piperidin-1-ylsulfonylphenyl)-3-(2-pyridin-3-ylethyl)urea
CFAMM00073956 CHEMBL2393164 Bioactive 1-[4-(2,8-diazaspiro[4.5]decan-2-ylsulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea
CFAMM00073949 CHEMBL2393169 Bioactive 1-[4-[[(3R,4R)-3-fluoropiperidin-4-yl]sulfamoyl]phenyl]-3-(pyridin-3-ylmethyl)urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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