CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD549
Family Name Synaptic vesicular amine transporter Inhibitor Tetrabenazine Family
No. of Seeds 13 No. of Other Members 425
Family Centroid CFAMM00074406 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily ABC transporter inhibitor Benzquinamide, amine transporter inhibitor Tetrabenazine Superfamily
Class Class 92

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Nicotinic acetylcholine receptor alpha subunit Ligand benzylis... 4 18
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Nicotinic acetylcholine receptor Ligand Cisatracurium Besylate... 1 0
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Glaziovine family 1 4
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Translocator protein Inhibitor Dextofisopam Family 3 250
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Vernakalant family 1 1
Ivabradine family 1 11
Dapoxetine family 3 40
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Kappa-type opioid receptor Ligand Fedotozine Family 1 11
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-br... 2 1
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Cytochrome P450 3A4 Inhibitor 1,2-diacetoxylycorine Family 4 19
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 2
Aromatase Inhibitor 2,3-dimethoxy-4'-amino-trans-stilbene Family 5 12
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 2 6
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
D(2) dopamine receptor Ligand Epidepride Family 31 66
Mu-type opioid receptor Ligand Cyprodime Family 12 8
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Transient receptor potential cation channel subfamily V member... 1 5
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
D(1A) dopamine receptor ligand DOXANTHINE family 3 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Regulator of G-protein signaling 12 and Beta-lactamase inhibit... 1 7
D(3) dopamine receptor ligand S 14297 family 1 2
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
Type-2 angiotensin II receptor ligand SureCN244657 family 7 11
Transient receptor potential cation channel subfamily V member... 14 7
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Sigma non-opioid intracellular receptor 1 ligand STK145388 family 1 4
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 5 2
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 6-met... 2 6
Prostaglandin D2 receptor 2 and Chemoattractant receptor-homol... 1 1
Melanin-concentrating hormone receptor 1 ligand 6-methoxy-4-[[... 2 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 7 13
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Histamine H3 receptor ligand SureCN6071181 family 2 1
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 1 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Free fatty acid receptor 1 ligand (3R,4R)-3-[4-(3,4-dimethylph... 4 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Sodium-dependent dopamine transporter and Transporter inhibito... 4 0
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Mu-type opioid receptor ligand N-[2-[(2-amino-2-oxoethyl)-[2-(... 1 0
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Potassium voltage-gated channel subfamily H member 2 ligand 1-... 2 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
Cytochrome P450 3A4 and Cellular tumor antigen p53 inhibitor P... 1 7
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 1
Sodium-dependent dopamine transporter inhibitor methyl (2R)-2-... 4 3
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 5 3
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-000I3M family 2 6
Benzazepines Metabolite N-Methylporphyroxine Family 1 2
3-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)amino... 3 0
7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline NP ZINC33345333... 21 3
Putative NP ZINC35363915 Family 10 0
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
NP (1s,5r,z)-2-(1-((4-methoxybenzyl)amino)ethylidene)-6,6-dime... 4 0
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0
Putative NP ZINC04287792 Family 2 0
Putative NP ZINC00526577 Family 12 0
2-(2,3,4,8,9,10-hexahydro-[1,4]dioxepino[2,3-g]isoquinolin-7-y... 4 0
Putative NP ZINC01322649 Family 2 0
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00074406 DAP000756 Approved Drug Tetrabenazine
CFAMM00074142 DNAP001637 Approved Drug (+-)-tetrahydropalmatine
CFAMM00074147 CHEMBL556545 Bioactive (10bS)-6-(3,4-dimethoxyphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide
CFAMM00074305 CHEMBL576222 Bioactive 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
CFAMM00074239 CHEMBL187525 Bioactive SureCN6320905
CFAMM00074272 CHEMBL1780005 Bioactive (2R)-9,10-dimethoxy-3-(2-methylprop-2-enyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol
CFAMM00074591 CHEMBL1743820 Bioactive (6S,10bR)-6-(3,4-dimethoxyphenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline;hydrobromide
CFAMM00074194 CHEMBL303770 Bioactive (2R,3R,11bR)-9,10-dimethoxy-2-methyl-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-ol
CFAMM00074676 CHEMBL569074 Bioactive AGN-PC-076LJ4
CFAMM00074176 CHEMBL61636 Bioactive (+)-Tetrabenazine
CFAMM00074344 CHEMBL571308 Bioactive AGN-PC-077AEJ
CFAMM00074133 DCL000062 Clinical Trial Drug AZD-9684

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26853 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543