CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD553
Family Name Thymidylate synthase inhibitor thymidine nucleoside analog Floxuridine/5-fluorouracil Family
No. of Seeds 8 No. of Other Members 48
Family Centroid CFAMM00074771 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily HBV, HIV polymerase, Thymidylate synthase inhibitor thymidine nucleoside analog Telbivudine Zidovudine Floxuridine Superfamily
Class Class 408

Cousin Family NamesSeedsMembers
HBV polymerase inhibitor thymidine nucleoside analog Telbivudi... 12 128
HIV reverse transcriptase inhibitor thymidine nucleoside analo... 4 14
Reverse transcriptase Inhibitor Sorivudine Family 3 16
P2Y purinoceptor 2 Inhibitor Diquafosol Family 2 44
Uridine Triacetate family 2 8
DNA polymerase Inhibitor 5-propenyl-arabinofuranosyluracil 5'-... 1 1
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyroph... 3 24
Uridine 5'-monophosphate synthase Inhibitor 5-fluoro-6-iodo-um... 3 2
P2Y purinoceptor 6 inhibitor [[(2R,3S,4R,5R)-3,4-dihydroxy-5-(... 1 3
P2Y purinoceptor 14 and P2Y purinoceptor 6 inhibitor N,N-dieth... 3 17
Reverse transcriptase/RNaseH inhibitor 6-amino-3-[(3S,4S,5R)-5... 2 1
Reverse transcriptase/RNaseH inhibitor [[[difluoro(phosphono)m... 1 2
Reverse transcriptase/RNaseH inhibitor ddUTP family 1 0
P2Y purinoceptor 6 and P2Y purinoceptor 2 inhibitor [[[[(2R,3S... 1 0
Thymidine phosphorylase inhibitor [(2R,3aR,4R,6R,6aR)-6-(hydro... 1 1
Pyrimidine Nucleotides Metabolite Orotidylic acid Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00074774 DAP000760 Approved Drug Trifluridine
CFAMM00074781 DNAP001503 Approved Drug Doxifluridine
CFAMM00074793 DAP000997 Approved Drug Idoxuridine
CFAMM00074771 DAP001245 Approved Drug Floxuridine/5-fluorouracil
CFAMM00074767 DNC013530 Investigative Drug L-5-iodo-2'-deoxyuridine
CFAMM00074779 DNC003034 Investigative Drug 5-Iododeoxyuridine
CFAMM00074777 DNC003038 Investigative Drug 5-Fluoro-2'-Deoxyuridine-5'-Monophosphate
CFAMM00074783 DNC002933 Investigative Drug 2'-Deoxyuridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42733 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543