CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD558
Family Name Type-1 angiotensin II receptor Ligand Telmisartan Family
No. of Seeds 4 No. of Other Members 181
Family Centroid CFAMM00074946 Functional Category Approved Drug with Human Metabolite
Superfamily angiotensin receptor ligand Candesartan Telmisartan Superfamily
Class Class 307

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Type-1 angiotensin II receptor Ligand Losartan Family 3 90
Type-1 angiotensin II receptor Ligand Candesartan Family 3 75
Type-1 angiotensin II receptor Ligand Olmesartan Family 13 65
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
BIBT986 family 7 96
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 2 1
Eluxadoline family 4 85
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Bombesin receptor subtype-3 ligand AGN-PC-07ZAKV family 13 23
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 16 34
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 11
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 3
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Type-1 angiotensin II receptor ligand SureCN9527437 family 2 34
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
Type-1 angiotensin II receptor ligand SureCN9402479 family 2 5
Bile acid receptor ligand 4-[[(2S)-2-[2-(4-chlorophenyl)-5,6-d... 4 12
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 25
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Microsomal triglyceride transfer protein large subunit inhibit... 7 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 5 14
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 6
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
C-C chemokine receptor type 5 ligand SureCN13543564 family 10 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 9 6
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 5
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Type-1 angiotensin II receptor ligand 2-butyl-3-[[4-(2-carboxy... 1 7
Type-1 angiotensin II receptor ligand 2-propyl-3-[[4-[2-(2H-te... 3 0
Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... 3 7
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 35 14
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 8 2
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 9 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 5 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 5 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 8 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Neuropeptide Y receptor type 5 ligand AGN-PC-02WBQH family 7 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Neuropeptide Y receptor type 5 ligand AGN-PC-077LX1 family 8 1
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Type-1A angiotensin II receptor ligand 2-[4-[[2-butyl-5-(tert-... 1 0
Thromboxane-A synthase inhibitor SureCN11474904 family 1 6
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 5
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
Type-1 angiotensin II receptor ligand AGN-PC-025PHO family 3 21
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 1 0
Type-1B angiotensin II receptor ligand SureCN9310003 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00074946 DAP000766 Approved Drug Telmisartan
CFAMM00074973 DCL000490 Clinical Trial Drug Azilsartan
CFAMM00074851 DNC012291 Investigative Drug CV-11194

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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