CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name 4-hydroxyphenylpyruvate dioxygenase Inhibitor Nitisinone Family
No. of Seeds 4 No. of Other Members 43
Family Centroid CFAMM00075868 Functional Category Approved Drug
Superfamily 4-hydroxyphenylpyruvate dioxygenase Inhibitor Nitisinone Superfamily
Class Class 445

Cousin Family NamesSeedsMembers
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Pan-DAC Inhibitor AR-42 Family 21 153
Urokinase-type plasminogen activator Inhibitor 1-[4-(2-oxo-2-p... 1 3
Liver carboxylesterase 1 Inhibitor 1-(4-nitro-phenyl)-2-phenyl... 2 7
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Amyloid beta A4 protein Inhibitor 1,6-bis(4'-nitrophenyl)-hexa... 3 60
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Telomerase reverse transcriptase Inhibitor 2,7-dinitroantraqui... 3 8
Acetylcholinesterase and Cholinesterase Inhibitor 5,6-dinitroa... 1 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(4-... 1 9
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 7
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor AGN-P... 2 0
Aromatase inhibitor AGN-PC-00Q2PJ family 4 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-[4-(4-nitr... 1 4
Free fatty acid receptor 1 ligand 3-[4-[2-(3-nitrophenyl)ethyn... 1 6


External ID

Functional Category

Molecule Name

CFAMM00075868 DAP000774 Approved Drug Nitisinone
CFAMM00075857 CHEMBL191847 Bioactive AC1N9FPX
CFAMM00075903 DNC011733 Investigative Drug 2-(2-Nitro-benzoyl)-cyclohexane-1,3-dione
CFAMM00075892 DNC005479 Investigative Drug 1,2-Bis-(3-nitro-phenyl)-ethane-1,2-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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