CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD567
Family Name Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family
No. of Seeds 7 No. of Other Members 137
Family Centroid CFAMM00076083 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Cyclooxygenase and Prostaglandin G/H synthase 2 Binder Superfamily
Class Class 448

Cousin Family NamesSeedsMembers
Sodium channel protein type 10 subunit alpha Ligand Tetracaine... 6 166
Retinoic acid receptor alpha Ligand Tamibarotene Family 5 95
Cyclooxygenase Inhibitor Diclofenac Family 6 37
Prostaglandin G/H synthase 1 Inhibitor Mesalazine Family 2 30
Cyclooxygenase Inhibitor Meclofenamic Acid Family 4 11
Serum albumin Inhibitor Iodipamide Family 2 23
Histamine H1 receptor Ligand Tranilast Family 5 125
Intedanib family 7 54
New permeability pathways Inhibitor 5-nitro-2-(3-phenylpropyla... 1 13
Neuraminidase Inhibitor 4-(acetylamino)-3-amino Benzoic Acid F... 2 27
Tyrosine-protein phosphatase non-receptor type 1 Ligand 2-(oxa... 3 11
High affinity nerve growth factor receptor and RAF proto-oncog... 3 29
Dihydroorotate dehydrogenase Inhibitor 2-(2-bromo-2-naphthamid... 1 2
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Inhibitor 4-[4-(benzyl... 2 19
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Fatty acid synthase Inhibitor 4-hydroxy-6-nitro-3-phenylquinol... 2 2
Glutamate receptor ionotropic, kainate 1 Ligand 2-(3-(3-bromop... 2 1
Transient receptor potential cation channel subfamily V member... 2 29
Bifunctional epoxide hydrolase 2 Inhibitor 4-(3-adamantan-1-yl... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 2-hydroxy-n,6-bis(... 2 7
Acetylcholinesterase Inhibitor 3-(2,5-dioxo-pyrrolidin-1-yl)-b... 2 4
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 8
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 1 3
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 6 13
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[7-[[4-(N'-... 7 15
Protease inhibitor AC1LALME family 2 1
Retinal dehydrogenase 1 and Menin inhibitor CHEMBL1507858 family 1 6
Prostaglandin E2 receptor EP4 subtype ligand SureCN3567929 family 10 3
Prostaglandin E2 receptor EP4 subtype ligand SureCN3581203 family 1 0
Prostaglandin E2 receptor EP4 subtype ligand SureCN3573573 family 3 0
Free fatty acid receptor 1 ligand AGN-PC-03ZC6J family 2 14
Neuropeptide Y receptor type 5 ligand SureCN3382773 family 1 13
Mitogen-activated protein kinase 14 inhibitor ethyl 3-(2,4-dif... 5 1
Prostaglandin E synthase inhibitor 4-chloro-2-[[1,3-dioxo-2-(1... 1 0
Prostaglandin E synthase inhibitor 2-[(2Z)-2-[3-methyl-1-(4-ni... 1 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C8 liga... 2 0
Caspase-9 and Caspase-8 inhibitor 4-fluoro-2-[[2-[[(2S)-3-meth... 1 11
Collagenase 3 inhibitor 4-[[4-oxo-6-(3-phenylprop-1-ynyl)quina... 2 9
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7494201 f... 5 14
Retinoic acid receptor beta and Retinoic acid receptor gamma l... 4 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 0
Glycogen phosphorylase, liver form inhibitor AGN-PC-00CDLB family 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 1
DNA-(apurinic or apyrimidinic site) lyase and ATP-dependent DN... 1 8
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 1 1
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 7 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 1 0
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Tankyrase-2 inhibitor 3-chloro-4-(4-methyl-2-oxo-1H-quinolin-7... 1 2
Protein farnesyltransferase subunit beta and Protein farnesylt... 2 4
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 1 2
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 1 0
Casein kinase I isoform alpha inhibitor methyl (2Z)-3-oxo-2-(2... 1 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-00ADLV family 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 1
Glucocorticoid receptor ligand AGN-PC-01X8JJ family 1 0
Holo-[acyl-carrier-protein] synthase inhibitor AGN-PC-00CGZN f... 1 0
Amino Acids and Derivatives Metabolite Xanthurenic acid Family 2 0
Prenol Lipids Metabolite alpha-Terpinyl anthranilate Family 1 4
NP Methyl 2-((3s,3a'r,8a's,8b's)-5-ethyl-1',2,3'-trioxo-3',3a'... 7 0
NP Methyl 3-acetyl-4-oxo-1,4-dihydroquinoline-8-carboxylate Fa... 2 0
2-oxo-1H-quinoline-4-carboxylate NP ZINC19735150 Family 5 4
Putative NP ZINC04061910 Family 6 3
Putative NP ZINC00192342 Family 2 1
Putative NP ZINC12659473 Family 5 0
Putative NP ZINC04043929 Family 4 1
(3S)-2-[(2-carboxylatophenyl)carbamoyl]-3,4-dihydro-1H-isoquin... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00076083 DAP000779 Approved Drug Mefenamic acid
CFAMM00076124 DNC002446 Investigative Drug Flufenamic Acid
CFAMM00075999 DNC006006 Investigative Drug 2-[(biphenyl-4-carbonyl)-amino]-benzoic acid
CFAMM00076040 DNC005899 Investigative Drug 2-[(2,2-diphenylacetyl)amino]benzoic acid
CFAMM00075982 DNC000413 Investigative Drug CGS 8515
CFAMM00076030 DNC003251 Investigative Drug 2-(cyclohexylamino)benzoic acid
CFAMM00076110 DNC007886 Investigative Drug 2-(3-biphenyl-4-yl-propionylamino)-benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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