CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD569
Family Name Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenolate Mofetil Family
No. of Seeds 4 No. of Other Members 353
Family Centroid CFAMM00076457 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenolate Mofetil Superfamily
Class Class 450

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Heat shock protein 90, putative Inhibitor Radicicol Family 3 42
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Endothelin-1 receptor Ligand PD156707 Family 41 211
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
cAMP-dependent protein kinase type II-beta regulatory subunit ... 34 81
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Inosine-5'-monophosphate dehydrogenase 1 and Inosine-5'-monoph... 1 0
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 6
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Tyrosyl-DNA phosphodiesterase 1 and Microtubule-associated pro... 1 1
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Protein kinase C alpha type inhibitor [2-(hydroxymethyl)-5-oxo... 2 4
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Estrogen receptor beta and Estrogen receptor ligand 7-bromo-3-... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor (E)-6-(3-br... 1 1
Inosine-5'-monophosphate dehydrogenase 2 inhibitor (E)-6-(3-ch... 1 2
Acetylcholinesterase inhibitor 5,7-Dimethoxy-2-methyl-indan-1-... 1 0
Protein kinase C alpha type inhibitor [(1R)-4-dodecoxy-1-(hydr... 1 18
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN56649... 3 2
Calmodulin inhibitor CHEMBL2408940 family 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 1
Survival motor neuron protein and Prelamin-A/C inhibitor CHEMB... 2 32
Inosine-5'-monophosphate dehydrogenase 2 inhibitor (E)-6-(3-cy... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor (E)-6-(4-hy... 1 10
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Inosine-5'-monophosphate dehydrogenase 2 and Inosine-5'-monoph... 1 14
Solute carrier organic anion transporter family member 1B1 and... 1 0
Sterol O-acyltransferase 1 and Sterol O-acyltransferase 2 inhi... 1 5
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 1 0
Prenol Lipids Metabolite Austalide A Family 5 4
Prenol Lipids Metabolite Scutigeral Family 1 0
Benzopyrans Metabolite (-)-trans-3,4-Dihydro-4,8-dihydroxy-3-m... 1 0
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0
Prenol Lipids Metabolite Rosmadial Family 1 0
5-chloro-4,6,8-trihydroxy-7-methoxy-3-methyl-3,4-dihydroisochr... 4 0
NP Ethyl 5-(tert-butyl)-3-oxo-8,9,10,11-tetrahydro-3h-benzofur... 1 0
NP 2,2,11,12-tetramethyl-3,4,8,9-tetrahydro-2h-cyclopenta[c]fu... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00076459 DAP000784 Approved Drug Mycophenolic acid
CFAMM00076457 DAP000783 Approved Drug Mycophenolate mofetil
CFAMM00076573 DNC002404 Investigative Drug Mycophenolic acid
CFAMM00076624 DNC011289 Investigative Drug mycophenolic hydroxamic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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