CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD575
Family Name Nuclear receptor subfamily 1 group I member 3 ligand piperazine derivative Meclizine Family
No. of Seeds 3 No. of Other Members 82
Family Centroid CFAMM00077130 Functional Category Approved Drug
Superfamily calcium channel, Histamine H1 receptor, nuclear receptor binding piperazine derivative Flunarizine Cyclizine Meclizine Superfamily
Class Class 115

Cousin Family NamesSeedsMembers
Serotonin re-uptake inhibitor tetralin derivative Sertraline f... 12 118
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Substance-P receptor Ligand Vestipitant Family 14 137
Zicronapine family 43 62
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sigma non-opioid intracellular receptor 1 ligand NCI60_038428 ... 5 9
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 18 4
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
D(1A) dopamine receptor and D(3) dopamine receptor ligand 2-[4... 1 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand 2-[2-[(... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 10
Nociceptin receptor and Mu-type opioid receptor ligand (NE)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and Sodium-dependent... 2 1
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 1 0
Glucose-6-phosphatase inhibitor SureCN8498194 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00077095 DAP001076 Approved Drug Buclizine
CFAMM00077130 DAP000795 Approved Drug Meclizine
CFAMM00077082 CHEMBL162422 Bioactive 1-benzyl-4-[(4-chlorophenyl)methyl]piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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