CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD576
Family Name Alpha-1B adrenergic receptor ligand Phenylephrine analog Methoxamine Family
No. of Seeds 9 No. of Other Members 56
Family Centroid CFAMM00077198 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Alpha-1 adrenergic receptor ligand Dextroamphetamine derivative Phenylephrine analog Superfamily
Class Class 149

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Acetylcholinesterase Inhibitor Rivastigmine Family 2 59
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Zucapsacin family 7 177
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 11 21
5-hydroxytryptamine receptor 2A Ligand C-(5-bromo-4,7-dimethox... 9 6
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 10
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Fatty-acid amide hydrolase 1 Inhibitor 8-phenyloctylcarbamic A... 12 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 2
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 0
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 3
Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-... 3 2
5-hydroxytryptamine receptor 2A ligand methyl 3-[4-[(2R)-2-ami... 1 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 3
Amine oxidase [flavin-containing] A inhibitor AGN-PC-054NIM fa... 1 0
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Tubulin alpha-1A chain inhibitor 1,2,3-trimethoxy-4-[(6R)-6-ni... 1 1
Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0
Putative NP ZINC00050501 Family 6 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00077198 DAP000796 Approved Drug Methoxamine
CFAMM00077200 DNC008883 Investigative Drug Racemic DOI
CFAMM00077199 DNC013658 Investigative Drug DOM
CFAMM00077177 DNC000359 Investigative Drug Butoxamine
CFAMM00077152 DNC013349 Investigative Drug (R)-1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine
CFAMM00077162 DNC013660 Investigative Drug Racemic DOTFM
CFAMM00077197 DNC012388 Investigative Drug 2-(3-Methoxy-phenyl)-1-methyl-ethylamine
CFAMM00077154 DNC013659 Investigative Drug 1-(4-ethyl-2,5-dimethoxyphenyl)propan-2-amine
CFAMM00077172 DNC012397 Investigative Drug 2-(2,5-Dimethoxy-phenyl)-1-methyl-ethylamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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