CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family
No. of Seeds 19 No. of Other Members 144
Family Centroid CFAMM00077624 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Superfamily
Class Class 459

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Gamma-aminobutyric acid B receptor Ligand Baclofen Family 5 12
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Cyclooxygenase Inhibitor Flurbiprofen Family 18 294
DNA Binder Chlorambucil Family 3 11
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Neprilysin Inhibitor Thiorphan Family 41 68
Chymase Inhibitor Phenylalanylmethane Family 1 8
Metabotropic glutamate receptor 1 Ligand 4-(1-amino-1-carboxy-... 3 5
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl ... 11 5
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Voltage-dependent calcium channel gamma-1 subunit Ligand 2-ami... 2 0
Voltage-dependent calcium channel gamma-1 subunit Ligand 2-ami... 1 2
Large neutral amino acids transporter small subunit 1 Inhibito... 2 4
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 14 2
Aminopeptidase B inhibitor AC1NUP6X family 2 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Metabotropic glutamate receptor 3 and Metabotropic glutamate r... 2 10
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 1
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor 6-[4-[(2S)-2-ca... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 0
Nitric oxide synthase, endothelial and Nitric oxide synthase, ... 2 2
Transcriptional activator protein LuxR inhibitor 3-(3-iodophen... 8 2
Putative NP ZINC20112399 Family 6 1
2-azaniumyl-2-benzyl-4-[2-carboxylatoethyl(oxido)phosphoryl]bu... 6 1
4-methyl-2-[[(E)-3-phenylprop-2-enyl]azaniumyl]pentanoate NP 2... 4 6
1-acetamido-3-propan-2-yl-3,4-dihydronaphthalene-2-carboxylate... 2 0
(2R,3S)-2-(benzenesulfonamido)-3-hydroxy-3-phenylpropanoate NP... 1 0


External ID

Functional Category

Molecule Name

CFAMM00077624 DAP000807 Approved Drug L-Phenylalanine
CFAMM00077641 DNC012958 Investigative Drug (S)-2-amino-2-p-tolylacetic acid
CFAMM00077618 DNC002461 Investigative Drug methyl L-phenylalaninate
CFAMM00077700 DNC002821 Investigative Drug 3-Methylphenylalanine
CFAMM00077662 DNC002550 Investigative Drug Beta-(2-Naphthyl)-Alanine
CFAMM00077638 DNC012953 Investigative Drug (S)-2-amino-2-phenylpropanoic acid
CFAMM00077683 DNC012970 Investigative Drug (S)-phenylglycine
CFAMM00077715 DNC003350 Investigative Drug PARA-(BENZOYL)-PHENYLALANINE
CFAMM00077739 DNC004279 Investigative Drug 4-amino-6-(4-octylphenyl)hexanoic acid
CFAMM00077714 DNC012962 Investigative Drug (S)-2-amino-2-o-tolylacetic acid
CFAMM00077587 DNC002600 Investigative Drug D-Phenylalanine
CFAMM00077562 DNC014695 Investigative Drug 4-Amino-3-(4-fluoro-phenyl)-butyric acid
CFAMM00077636 DNC012956 Investigative Drug 2-amino-2-(2,4-difluorophenyl)acetic acid
CFAMM00077713 DNC012961 Investigative Drug 2-amino-2-(2-fluorophenyl)acetic acid
CFAMM00077569 DNC003408 Investigative Drug Iodo-Phenylalanine
CFAMM00077585 DNC000016 Investigative Drug (R,S)-4-phosphonophenylglycine
CFAMM00077635 DNC012957 Investigative Drug 2-amino-2-(2,3-difluorophenyl)acetic acid
CFAMM00077712 DNC012967 Investigative Drug rac-2-amino-4-phenylbutanoic acid
CFAMM00077718 DNC004313 Investigative Drug 3-amino-5-(4-octylphenyl)pentanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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