CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD590
Family Name Estrogen receptor beta Ligand Conjugated Estrogens Family
No. of Seeds 12 No. of Other Members 210
Family Centroid CFAMM00078328 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Estrogen receptor beta Ligand Conjugated Estrogens Superfamily
Class Class 463

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Dihydroorotate dehydrogenase Inhibitor Atovaquone Family 1 4
Retinoid X receptor Ligand Bexarotene Family 7 492
Oestrogen receptor ligand steroid Estradiol derivative Fulvest... 3 64
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Oestrogen receptor ligand steroid Estradiol Family 18 147
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Mestranol Family 2 29
Danthron family 11 141
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Glucose-6-phosphate translocase Inhibitor Mumbaistatin Family 3 11
Bile acid receptor Ligand SR-45023A (apomine) Family 3 34
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estrad... 6 16
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-isopropyl Estrad... 3 0
Steryl-sulfatase Inhibitor 2-ethylestradiol 3,17-o,o-bis-sulfa... 1 2
Carbonic anhydrase 2 and Steryl-sulfatase Inhibitor 2-methoxye... 2 7
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
DNA topoisomerase 2-beta Inhibitor Demethylzeylasterone Family 1 2
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Indoleamine 2,3-dioxygenase 1 Inhibitor Garveatin E Family 2 0
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Tyrosine-protein phosphatase non-receptor type 1 Ligand Kuwano... 3 3
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Estrogen receptor and Estrogen receptor beta ligand SureCN1784... 1 2
Estrogen receptor and Estrogen receptor beta ligand 10-[(8S,9S... 1 0
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-2-chloro-13-methyl... 1 5
Estrogen receptor beta and Estrogen receptor ligand 4-bromo-9a... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Androgen receptor and Estrogen receptor ligand estradiol benzo... 1 29
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-2-bromo-13-methyl-... 1 1
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 1 1
Thromboxane A2 receptor ligand AGN-PC-003UTI family 1 0
Glucocorticoid receptor ligand SureCN4024251 family 1 0
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3-bromophe... 1 1
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3,4-dichlo... 1 3
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-benzyl-3,17-... 1 1
Steroid hormone receptor ERR1 and Steroid hormone receptor ERR... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 4
Aldo-keto reductase family 1 member C3 inhibitor (2R,8'R,9'S,1... 1 0
Aldo-keto reductase family 1 member C3 inhibitor methyl (8R,9S... 1 0
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 6 13
Steryl-sulfatase inhibitor [(8R,9S,13S,14S)-13-methyl-17-oxo-7... 1 9
Aromatase inhibitor AGN-PC-075LLF family 1 0
Acenes Metabolite Lacinilene C Family 2 3
Putative NP ZINC49600254 Family 8 2
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00078328 DAP000818 Approved Drug Conjugated Estrogens
CFAMM00078499 DAP001020 Approved Drug Estrone
CFAMM00078294 DNCL001633 Clinical Trial Drug Bazedoxifene/ conjugated estrogens
CFAMM00078275 DNC003339 Investigative Drug Equilin
CFAMM00078406 DNC006189 Investigative Drug 16-beta-ethoxymethyl-estrone
CFAMM00078405 DNC006186 Investigative Drug 16-(2',2'-Dimethyl)-propylidene-estrone
CFAMM00078287 DNC003634 Investigative Drug EMATE
CFAMM00078404 DNC006187 Investigative Drug 16-isobutylidene-estrone
CFAMM00078493 DNC002937 Investigative Drug Equilenin
CFAMM00078384 DNC006153 Investigative Drug 6-oxo-estrone
CFAMM00078309 DNC006192 Investigative Drug 6-oxo-16-formyl-estrone
CFAMM00078432 DNC006166 Investigative Drug ethyl estrone-16-methylcarboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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