CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFAD591
Family Name Heat shock protein 90, putative Inhibitor Cromoglicate Family
No. of Seeds 14 No. of Other Members 2827
Family Centroid CFAMM00085405 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Heat shock protein 90, putative Inhibitor Cromoglicate Superfamily
Class Class 197

Cousin Family NamesSeedsMembers
DNA binder anthracycline analog Doxorubicin family 9 32
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
DNA topoisomerase 2-beta Inhibitor Etoposide Family 3 29
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Salicin family 5 629
Chromomycin A3 family 7 14
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Acetylcholinesterase Inhibitor Territrem B Family 3 21
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Protein kinase C alpha type and Protein kinase C beta type Inh... 7 1
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Prostaglandin D2 receptor 2 Ligand 2-(2-benzoyl-4-bromophenoxy... 4 35
Tyrosine-protein phosphatase non-receptor type 1 Ligand Phelli... 1 1
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 160
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Protein kinase C alpha type and Protein kinase C beta type Inh... 2 1
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Neutrophil elastase Inhibitor E-6-o-p-methoxycinnamoyl Scandos... 2 68
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 6
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Tyrosyl-DNA phosphodiesterase 1 and Microtubule-associated pro... 1 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 4 28
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Protein kinase C theta type and Protein kinase C eta type inhi... 7 4
Squalene synthase inhibitor (6R,7R)-1-[(4S,5R)-4-acetyloxy-5-m... 8 5
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Protein FimH and Type 1 fimbiral adhesin FimH inhibitor methyl... 1 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 7
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 2 2
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Solute carrier organic anion transporter family member 1B1 and... 2 4
Protein kinase C alpha type inhibitor [(1R)-4-dodecoxy-1-(hydr... 1 18
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 1 1
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 1 0
Cysteinyl leukotriene receptor 1 ligand 7-[(4R,5R,6E,8E,10Z,13... 1 3
Calmodulin inhibitor CHEMBL2408940 family 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 1
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
Multidrug resistance protein 1 inhibitor CHEMBL1 family 2 0
Survival motor neuron protein and Prelamin-A/C inhibitor CHEMB... 2 32
Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dim... 3 2
NS5B protein inhibitor AC1LAB50 family 2 1
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 4 10
Ribosomal protein S6 kinase alpha-3 inhibitor [(2S,3S,4S,5R,6S... 1 0
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[3... 1 4
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Prothrombin inhibitor sodium;[3-ethoxycarbonyl-2-[[3-ethoxycar... 1 6
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (2Z)-... 2 10
72 kDa type IV collagenase inhibitor [(2S,3S,4R)-4-(4,5-dihydr... 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Acenes Metabolite Aflatoxin B1 dialcohol Family 1 0
Prenol Lipids Metabolite Austalide A Family 5 4
Benzopyrans Metabolite (-)-trans-3,4-Dihydro-4,8-dihydroxy-3-m... 1 0
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0
Benzofurans Metabolite (R)-Bitalin A Family 1 9
Prenol Lipids Metabolite Rosmadial Family 1 0
Acenes Metabolite 1-Hydroxypyrene glucuronide Family 1 2
Putative NP ZINC31165975 Family 4 0
Putative NP ZINC02398203 Family 1 0
NP (z)-2-(2,3-dimethoxybenzylidene)-3-oxo-2,3-dihydrobenzofura... 9 0
NP (z)-2-(4-isopropylbenzylidene)-3-oxo-2,3-dihydrobenzofuran-... 16 0
1,3-dimethylcyclohepta[c]furan-8-one NP 6-(4-hydroxy-3-iodo-5-... 13 1
NP Ethyl 3-(4-bromophenyl)-7-((methylsulfonyl)oxy)-4-oxo-4h-ch... 9 1
NP 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6-ethyl-4-oxo-4h-ch... 33 4
NP 2-((3-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-6-ethyl-4... 10 0
4-acetylphenyl (1'S,2'R,6'R,9'R)-dispiro[cyclohexane-1,4'-[3,5... 4 2
NP (z)-6-((4-bromobenzyl)oxy)-2-(3,4-dimethoxybenzylidene)benz... 13 2
NP (z)-2-((2-methyl-2h-chromen-3-yl)methylene)-3-oxo-2,3-dihyd... 74 1
NP 2-((3-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-2-methyl-... 2 0
benzenesulfonate NP (z)-3-oxo-2-(3,4,5-trimethoxybenzylidene)-... 26 0
NP (2r,3r,4s,5r,6s)-2-(acetoxymethyl)-6-(2-propionylphenoxy)te... 2 3
4-oxochromene-2-carboxylate NP Ethyl 3-(7-(2-(4-bromophenyl)-2... 10 1
NP Ethyl 7-((2-chlorobenzoyl)oxy)-3-(2-methoxyphenyl)-4-oxo-4h... 37 1
Putative NP ZINC09486076 Family 56 0
bromobenzoate NP ZINC09346025 Family 20 0
1-benzofuran-3-one NP ZINC02367988 Family 9 0
benzenesulfonate NP ZINC09051160 Family 47 2
Putative NP ZINC02424323 Family 24 0
2-(trifluoromethyl)chromen-4-one NP ZINC01929476 Family 25 0
Putative NP ZINC09051797 Family 10 0
Putative NP ZINC09306352 Family 7 0
ethyl 4-[2-(hydroxyamino)-2-(2-hydroxy-4-oxocyclohexa-2,5-dien... 1 0
Putative NP ZINC09575270 Family 7 0
Putative NP ZINC01135787 Family 3 0
Putative NP ZINC09517236 Family 5 0
bromobenzoate NP ZINC11865066 Family 6 0
Putative NP ZINC08382321 Family 8 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00085405 DAP000819 Approved Drug Cromoglicate
CFAMM00079001 DNC000381 Investigative Drug Calpastatin
CFAMM00079348 DNC013766 Investigative Drug Patuletin 3-O-beta-D-galactoside
CFAMM00079844 DNC014385 Investigative Drug SOPHORICOSIDE
CFAMM00080182 DNC000569 Investigative Drug Disodium cromoglycate
CFAMM00081922 DNC013593 Investigative Drug ASTRAGALIN
CFAMM00081927 DNC013594 Investigative Drug kaempferol-3-O-(2''-O-galloyl)-glucoside
CFAMM00082465 DNC009165 Investigative Drug TILIROSIDE
CFAMM00083043 DNC013662 Investigative Drug apigenin-7-O-beta-D-glucuronide methyl ester
CFAMM00083044 DNC013663 Investigative Drug apigenin-7-O-beta-D-glucuronide
CFAMM00083954 DNC013752 Investigative Drug asterric acid
CFAMM00084446 DNC002527 Investigative Drug Daidzin
CFAMM00084942 DNC009519 Investigative Drug BAICALIN
CFAMM00085538 DNC008648 Investigative Drug Icariside II