CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD594
Family Name Phospholipase A2 Inhibitor Quinacrine Family
No. of Seeds 13 No. of Other Members 95
Family Centroid CFAMM00086969 Functional Category Approved Drug with Natural Product
Superfamily Histamine N-methyltransferase inhibitor aminoquinoline Amodiaquine Phospholipase A2 inhibitor Quinacrine Superfamily
Class Class 409

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
DNA topoisomerase 2-beta inhibitor acridine derivative Amsacri... 1 4
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Calcium-activated potassium channel subunit alpha-1 Ligand Qui... 3 46
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Histamine N-methyltransferase inhibitor aminoquinoline Amodiaq... 8 23
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
DNA Binder Elliptinium Acetate Family 11 116
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 67 130
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Dihydroorotate dehydrogenase Inhibitor LY214352 Family 2 17
Cytochrome b Inhibitor 2-nonyl-4-hydroxyquinoline N-OXIDE Family 2 22
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Acetylcholinesterase Inhibitor Velnacrine Family 2 29
Platelet-derived growth factor receptor alpha and Platelet-der... 6 8
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor beta and Epidermal gro... 3 7
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 0
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
E3 ubiquitin-protein ligase Mdm2 Inhibitor NSC-66811 Family 4 27
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 5-aminoquinolin-8-ol F... 3 16
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 38 35
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-hydroxy-5-(2-methyl... 2 1
Metabotropic glutamate receptor 5 Ligand (3-(2-methylquinolin-... 3 6
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Prostaglandin G/H synthase 2 Inhibitor 5-methoxy-2-(4-(methyls... 3 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor ligand 4-fluoro-2-[5,5,5-trifluoro-4-h... 3 9
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 30
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN525... 8 8
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 5 1
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
D(2) dopamine receptor ligand 129722-25-4 family 2 2
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Proto-oncogene tyrosine-protein kinase Src inhibitor AC1NS5MA ... 3 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-09Q7W... 7 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Transient receptor potential cation channel subfamily V member... 1 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN4... 9 2
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Steroid hormone receptor ERR1 and Steroid hormone receptor ERR... 1 4
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[[4... 7 4
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 1 3
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
D(1A) dopamine receptor and D(2) dopamine receptor ligand (6aR... 3 6
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
D(2) dopamine receptor ligand SureCN10575660 family 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
Proteinase-activated receptor 1 ligand (3R,3aS,4S,4aR,8aS,9aR)... 1 11
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PJ... 4 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 9 0
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Small conductance calcium-activated potassium channel protein ... 1 1
Histidine-rich protein PFHRP-II inhibitor AGN-PC-075SYG family 1 0
2,4,6-trimethyl-2,3-dihydrofuro[3,2-c]quinoline NP ZINC0009476... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00086969 DAP000825 Approved Drug Quinacrine
CFAMM00086899 DCL000747 Clinical Trial Drug Cethrin
CFAMM00087021 DCL000871 Clinical Trial Drug LJP-1082
CFAMM00086904 DNC011231 Investigative Drug N-n-pentyl-7-methoxytacrine hydrochloride
CFAMM00086903 DNC011236 Investigative Drug N-n-dodecyl-7-methoxytacrine hydrochloride
CFAMM00086902 DNC011237 Investigative Drug 7-methoxytacrine
CFAMM00086901 DNC011234 Investigative Drug N-n-octyl-7-methoxytacrine hydrochloride
CFAMM00086962 DNC001180 Investigative Drug Quinacrine dihydrochloride
CFAMM00086907 DNC011232 Investigative Drug N-n-hexyl-7-methoxytacrine hydrochloride
CFAMM00086900 DNC011235 Investigative Drug N-n-nonyl-7-methoxytacrine hydrochloride
CFAMM00086913 DNC000408 Investigative Drug CGP 40336A
CFAMM00086906 DNC011233 Investigative Drug N-n-heptyl-7-methoxytacrine hydrochloride
CFAMM00086905 DNC011230 Investigative Drug N-n-propyl-7-methoxytacrine hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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