CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD599
Family Name Tyrosinase Inhibitor Monobenzone Family
No. of Seeds 6 No. of Other Members 197
Family Centroid CFAMM00087175 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Tyrosinase Inhibitor Monobenzone Superfamily
Class Class 470

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Salicin family 5 629
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Glucokinase Inhibitor R7201 Family 22 105
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
TS-071 family 8 36
Glycoprotein IIb/IIIa receptor Ligand Accutin Family 4 24
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Carbonic anhydrase 2 Inhibitor Sulfamic Acid Chroman-2-ylmethy... 1 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 6-ph... 1 18
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Androgen receptor Ligand 2-methoxy-4-(o-tolyloxy)benzonitrile ... 5 12
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Carbonic anhydrase 2 Inhibitor Guaiacol Family 1 14
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 2 1
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-meth... 4 12
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Beta-secretase 1 Inhibitor Eckol Family 6 40
Prostaglandin G/H synthase 1 Inhibitor Acetic Acid 2-heptylsel... 1 14
4-hydroxyphenylpyruvate dioxygenase Inhibitor (4-hydroxy-pheno... 1 13
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Survival motor neuron protein and Lysine-specific demethylase ... 1 16
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Vitamin D3 receptor ligand (3E,5E)-6-[3-[[3,4-bis(hydroxymethy... 2 4
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
Amine oxidase [flavin-containing] B inhibitor 4-[4-[(3-chlorop... 2 3
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Arachidonate 5-lipoxygenase inhibitor SureCN9727660 family 1 0
Arachidonate 5-lipoxygenase inhibitor SureCN9727677 family 1 2
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 6-[te... 1 0
NS5B protein inhibitor (Z)-4-[2-(3-cyanopropoxy)phenyl]-4-hydr... 2 0
Cannabinoid receptor 1 and Monoglyceride lipase ligand 4-(4-ph... 4 4
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 17
Phenylacetic Acid Derivatives Metabolite 3,4,5-Trimethoxypheny... 1 7
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
Putative NP ZINC35270729 Family 12 0
NP (r)-(2-(4-isopropoxybenzyl)-4-methyl-4,5-dihydrooxazol-4-yl... 3 0
2-methyl-2H-chromene-3-carbaldehyde NP 2-methyl-2h-chromene-3-... 2 1
NP Chemdiv1 023678 Family 4 3
Putative NP ZINC00526277 Family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00087175 DAP000830 Approved Drug Monobenzone
CFAMM00087060 DNC014194 Investigative Drug DAEDALIN A
CFAMM00087214 DNC009620 Investigative Drug 4-(4-propoxyphenoxy)phenol
CFAMM00087213 DNC009621 Investigative Drug 4-(4-butoxyphenoxy)phenol
CFAMM00087212 DNC009622 Investigative Drug 4-(4-(pentyloxy)phenoxy)phenol
CFAMM00087196 DNC010104 Investigative Drug 4-(2-Hydroxyethoxy)-1-naphthol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543