CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD6
Family Name Serine/threonine-protein kinase B-raf inhibitor diaryl urea analog Sorafenib Family
No. of Seeds 12 No. of Other Members 93
Family Centroid CFAMM00000702 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Serine/threonine-protein kinase B-raf inhibitor diaryl urea analog Sorafenib Superfamily
Class Class 6

Cousin Family NamesSeedsMembers
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
E7050 family 2 13
MK-6096 family 3 69
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Receptor-type tyrosine-protein kinase FLT3 and Macrophage colo... 9 8
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Cathepsin S and Cathepsin K inhibitor AGN-PC-09M7MI family 2 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 8 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 7
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Growth hormone secretagogue receptor type 1 ligand 2-methyl-6-... 2 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 11 8
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 11 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 5 0
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2768193 family 2 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Glucagon receptor ligand SureCN2647807 family 3 7
Coagulation factor X inhibitor 3-Oxybenzamide 48 family 1 12
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 1 3
Transient receptor potential cation channel subfamily V member... 2 0
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 5 0
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 1 0
Coagulation factor X inhibitor 3-Oxybenzamide 15 family 1 1
Cytochrome P450 1A2 and Metabotropic glutamate receptor 4 liga... 1 2
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Metabotropic glutamate receptor 2 ligand 8-chloro-6-[4-[(6-chl... 9 0
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00000702 DAP000006 Approved Drug Sorafenib
CFAMM00000675 DNAP001694 Approved Drug Regorafenib
CFAMM00000643 CHEMBL350747 Bioactive SureCN549001
CFAMM00000716 CHEMBL1688863 Bioactive AGN-PC-00AFLJ
CFAMM00000701 CHEMBL394826 Bioactive 2qu5
CFAMM00000613 CHEMBL2397143 Bioactive N-methyl-4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]cyclohexyl]oxypyridine-2-carboxamide
CFAMM00000612 CHEMBL2397142 Bioactive 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]cyclohexyl]oxy-N,N-dimethylpyridine-2-carboxamide
CFAMM00000648 CHEMBL1807196 Bioactive 4-[3-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
CFAMM00000609 CHEMBL2397146 Bioactive 5-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]cyclohexyl]oxy-N-methylpyridine-2-carboxamide
CFAMM00000624 CHEMBL2397137 Bioactive 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]cyclohexyl]oxy-N-methylpyridine-2-carboxamide
CFAMM00000608 CHEMBL2397149 Bioactive N-methyl-4-[4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxamide
CFAMM00000717 CHEMBL1688862 Bioactive AGN-PC-093OAG

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21794 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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