CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocaine Family
No. of Seeds 13 No. of Other Members 136
Family Centroid CFAMM00087589 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Dopamine reuptake and Noradrenergic re-uptake Inhibitor Cocaine Superfamily
Class Class 473

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
Sodium channel protein type 10 subunit alpha Ligand Tetracaine... 6 166
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Muscarinic acetylcholine receptor M5 ligand Tropane alkaloid A... 18 12
Sodium channel protein type 5 subunit alpha Ligand Hexylcaine ... 4 94
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Sodium-dependent dopamine transporter Inhibitor Ioflupane I-12... 130 181
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 1 6
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-4-ni... 1 7
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor [(1R)-1-(... 2 5
Sodium-dependent dopamine transporter and Muscarinic acetylcho... 2 1
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sodium-dependent dopamine transporter and Sodium-dependent ser... 4 1
Sodium-dependent dopamine transporter and Transporter inhibito... 5 1
Peptidyl-prolyl cis-trans isomerase FKBP1A and Peptidyl-prolyl... 4 27
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 18
5-hydroxytryptamine receptor 1A ligand SureCN7763400 family 4 9
Sodium-dependent dopamine transporter inhibitor (1R,3S)-3-(4-a... 1 0
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 13 22
Muscarinic acetylcholine receptor M3 ligand 3-[8-methyl-8-(2-p... 3 0
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Substance-P receptor ligand AGN-PC-03NGZP family 3 0
Sodium-dependent dopamine transporter and Transporter inhibito... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Sodium-dependent dopamine transporter inhibitor ethyl (3S,4S)-... 6 11
Sodium-dependent serotonin transporter and Transporter inhibit... 2 4
Sodium-dependent serotonin transporter and Transporter inhibit... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 5 1
Substance-P receptor ligand (3aR,4R,5S,7aS)-5-[(1R)-1-[3,5-bis... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (4aR,... 1 0
Sodium-dependent dopamine transporter inhibitor 2-(4-nitrophen... 2 1
Acetylcholine-binding protein and Soluble acetylcholine recept... 1 2
Huntingtin and Inositol monophosphatase 1 inhibitor CHEMBL1493... 1 1


External ID

Functional Category

Molecule Name

CFAMM00087589 DAP000834 Approved Drug Cocaine
CFAMM00087535 CHEMBL174532 Bioactive methyl (1R,3S)-3-benzoyloxy-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane-4-carboxylate
CFAMM00087630 CHEMBL217456 Bioactive SureCN14723770
CFAMM00087519 CHEMBL317362 Bioactive SureCN14075561
CFAMM00087565 CHEMBL310650 Bioactive methyl (3S,4R)-3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00087635 CHEMBL95775 Bioactive 2-phenylethyl (3S,4R)-3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00087593 CHEMBL316634 Bioactive benzyl (3S,4R)-3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00087543 CHEMBL99038 Bioactive propan-2-yl (3S,4R)-3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00087556 CHEMBL175195 Bioactive methyl (1R,3S)-3-(4-azidobenzoyl)oxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate
CFAMM00087646 CHEMBL40883 Bioactive (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3,5-dimethylbenzoate
CFAMM00087529 CHEMBL284394 Bioactive (1R,3S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylic acid
CFAMM00087638 DNC011093 Investigative Drug COCAINE.HCL
CFAMM00087604 DNC012473 Investigative Drug PSEUDOCOCAINE

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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