CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD604
Family Name Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Family
No. of Seeds 14 No. of Other Members 199
Family Centroid CFAMM00087688 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Biogenic amine receptor ligand Terfenadine Trihexyphenidyl Superfamily
Class Class 89

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Histamine H1 receptor Ligand Terfenadine Family 3 50
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Opioid receptor ligand opiate Levorphanol Family 18 537
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Delta-type opioid receptor Ligand Loperamide Family 8 55
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Pitolisant family 4 24
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Adenosine receptor A3 and D(2) dopamine receptor Ligand (+)-bu... 5 14
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 5 14
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand Sur... 6 53
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-076TWX... 8 5
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Vesicular acetylcholine transporter inhibitor BENZOVESAMICOL f... 7 4
Histamine H3 receptor ligand SureCN5551955 family 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 1 1
Sigma non-opioid intracellular receptor 1 ligand SureCN5315520... 3 11
D(2) dopamine receptor and D(3) dopamine receptor ligand 4-(4-... 1 3
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 3
Vesicular acetylcholine transporter inhibitor 2-Naphthalenol, ... 3 2
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Vesicular acetylcholine transporter inhibitor (1R,2R)-2-spiro[... 3 2
Squalene synthase inhibitor 3-[2-(4-phenylphenyl)ethynyl]-1-az... 2 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 4
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 1
C-C chemokine receptor type 1 ligand SureCN9108653 family 2 5
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 7
Alpha-1A adrenergic receptor and Transporter ligand AGN-PC-00M... 2 2
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-04... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand (2S,... 5 5
C-C chemokine receptor type 1 ligand SureCN9108276 family 1 0
Membrane primary amine oxidase and Amine oxidase [flavin-conta... 2 0
C-C chemokine receptor type 1 ligand SureCN9108965 family 1 0
Dibenzocycloheptenes Metabolite E-10-Hydroxynortriptyline Family 1 0
7-phenyl-1,3-diazaadamantan-6-ol NP ZINC32124180 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00087801 DAP001120 Approved Drug Cycrimine
CFAMM00087688 DAP001122 Approved Drug Trihexyphenidyl
CFAMM00087778 DAP001133 Approved Drug Diphenidol
CFAMM00087893 DAP001110 Approved Drug Procyclidine
CFAMM00087844 DAP001532 Approved Drug Trihexyphenidyl HCl
CFAMM00087799 DAP001125 Approved Drug Biperiden
CFAMM00087729 DAP000836 Approved Drug Tridihexethyl
CFAMM00087679 CHEMBL400598 Bioactive (R)-PROCYCLIDINE
CFAMM00087695 CHEMBL549790 Bioactive 2-[(1R,5R)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl]-1,1-diphenylethanol;bromide
CFAMM00087776 DNC010157 Investigative Drug diphenyl(piperidin-4-yl)methanol
CFAMM00087720 DNC007495 Investigative Drug 4-phenyl-1-(3-phenylpropyl)piperidin-4-ol
CFAMM00087719 DNC007494 Investigative Drug 1-(3,3-diphenylpropyl)-4-phenylpiperidin-4-ol
CFAMM00087718 DNC007497 Investigative Drug 4-phenyl-1-(1-phenylpropan-2-yl)piperidin-4-ol
CFAMM00087717 DNC007496 Investigative Drug 1-benzyl-4-phenylpiperidin-4-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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