CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Cholesterol side-chain cleavage enzyme, mitochondrial and Aromatase Inhibitor Aminoglutethimide Family
No. of Seeds 9 No. of Other Members 26
Family Centroid CFAMM00088899 Functional Category Approved Drug
Superfamily Aromatase inhibitor Aminoglutethimide, CYP2D6 inhibitor Glutethimide Superfamily
Class Class 478

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Motilin receptor Ligand GSK962040 Family 30 457
Pan-DAC Inhibitor AR-42 Family 21 153
Proto-oncogene tyrosine-protein kinase Src Inhibitor ISO24 Family 3 9
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1


External ID

Functional Category

Molecule Name

CFAMM00088899 DAP000842 Approved Drug Aminoglutethimide
CFAMM00088915 DNC004612 Investigative Drug 3-(4-Amino-phenyl)-3-butyl-piperidine-2,6-dione
CFAMM00088906 DNC004636 Investigative Drug 3-(4-Amino-phenyl)-3-hexyl-piperidine-2,6-dione
CFAMM00088876 DNC004519 Investigative Drug 3-(4-Amino-phenyl)-3-ethyl-pyrrolidine-2,5-dione
CFAMM00088912 DNC004617 Investigative Drug 3-(4-Amino-phenyl)-3-pentyl-piperidine-2,6-dione
CFAMM00088893 DNC004525 Investigative Drug 3-(4-Amino-phenyl)-3-methyl-pyrrolidine-2,5-dione
CFAMM00088911 DNC004615 Investigative Drug 3-(4-Amino-phenyl)-3-heptyl-piperidine-2,6-dione
CFAMM00088910 DNC004635 Investigative Drug 3-(4-Amino-phenyl)-3-propyl-piperidine-2,6-dione
CFAMM00088892 DNC004526 Investigative Drug 3-(4-Amino-phenyl)-pyrrolidine-2,5-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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