CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD612
Family Name Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor Lapatinib Family
No. of Seeds 9 No. of Other Members 65
Family Centroid CFAMM00088935 Functional Category Approved Drug
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor Lapatinib Superfamily
Class Class 481

Cousin Family NamesSeedsMembers
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Receptor tyrosine-protein kinase erbB-2 Inhibitor ARRY-380 Family 2 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 2 3
Epidermal growth factor receptor and Mitogen-activated protein... 5 19
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 1 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Epidermal growth factor receptor ligand [4-(3-chloro-4-fluoroa... 2 5
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 4 24
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00088935 DAP000853 Approved Drug Lapatinib
CFAMM00088944 CHEMBL2437233 Bioactive 1-[4-[[5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]methyl]piperazin-1-yl]ethanone;1-methyl-4-methylsulfonylbenzene
CFAMM00088978 CHEMBL475769 Bioactive AGN-PC-0791HA
CFAMM00088983 CHEMBL2437224 Bioactive N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfinylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid
CFAMM00088982 CHEMBL2437227 Bioactive N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[2-(2,2,2-trifluoroethylsulfonyl)ethylamino]methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid
CFAMM00088934 CHEMBL1076241 Bioactive Tykerb
CFAMM00088981 CHEMBL2437226 Bioactive 2-[[5-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]methylamino]ethanesulfonamide;4-methylbenzenesulfonic acid
CFAMM00088939 DCL000344 Clinical Trial Drug Tykerb
CFAMM00088954 DNC010650 Investigative Drug Lapatinib ditosylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27433 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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