CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD613
Family Name Oestrogen receptor ligand steroid Estradiol Family
No. of Seeds 18 No. of Other Members 147
Family Centroid CFAMM00089059 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Oestrogen receptor ligand steroid Estradiol derivative Superfamily
Class Class 223

Cousin Family NamesSeedsMembers
Oestrogen receptor ligand steroid Estradiol derivative Fulvest... 3 64
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Oestrogen receptor ligand Dienestrol Family 35 440
Oestrogen receptor Ligand Mestranol Family 2 29
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Bile acid receptor Ligand SR-45023A (apomine) Family 3 34
Estrogen receptor beta Ligand 1-chloro-6-(4-hydroxyphenyl)-2-n... 12 23
Epidermal growth factor receptor Ligand 2-(4,5-dihydroxy-indan... 2 1
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Oestrogen receptor and Estrogen receptor beta Ligand 1-bromo-6... 3 4
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
Steryl-sulfatase Inhibitor 2-ethylestradiol 3,17-o,o-bis-sulfa... 1 2
Carbonic anhydrase 2 and Steryl-sulfatase Inhibitor 2-methoxye... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor 4-adamantyl Resorcinol Family 1 1
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Estrogen receptor and Estrogen receptor beta ligand SureCN1784... 1 2
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Estrogen receptor and Estrogen receptor beta ligand 10-[(8S,9S... 1 0
Estrogen receptor beta and Estrogen receptor ligand 3-chloro-4... 2 0
Estrogen receptor ligand (8S,9R,11S,13S,14S,17S)-11-[4-[2-[2-(... 1 4
Estrogen receptor beta and Estrogen receptor ligand 4-bromo-9a... 3 0
Progesterone receptor and Glucocorticoid receptor ligand (8S,1... 6 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Glucocorticoid receptor ligand SureCN4024251 family 1 0
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3-bromophe... 1 1
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3,4-dichlo... 1 3
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-benzyl-3,17-... 1 1
Aldo-keto reductase family 1 member C3 inhibitor (2R,8'R,9'S,1... 1 0
Aldo-keto reductase family 1 member C3 inhibitor methyl (8R,9S... 1 0
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
Putative NP ZINC03881930 Family 8 5
[(E)-3-carboxy-2-(5-methyl-2-oxidophenyl)prop-2-enyl]-(2-pheny... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00089178 DAP001019 Approved Drug Estriol
CFAMM00089177 DAP001018 Approved Drug Ethinyl Estradiol
CFAMM00089059 DAP000854 Approved Drug Estradiol
CFAMM00089208 CHEMBL1627868 Bioactive (8S,9S,11S,13S,14S,17S)-11-but-3-enyl-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CFAMM00089174 CHEMBL1627822 Bioactive (8R,9S,13R,14S)-13-(hydroxymethyl)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
CFAMM00089094 CHEMBL260660 Bioactive (13S,14S,17S)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-2,17-diol
CFAMM00089047 CHEMBL223967 Bioactive 6-Dehydroestradiol
CFAMM00089053 CHEMBL121458 Bioactive 17beta-Dihydroequilin
CFAMM00089082 DNC002516 Investigative Drug 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
CFAMM00089153 DNC006180 Investigative Drug 16-isobutylidene-estradiol
CFAMM00089197 DNC014856 Investigative Drug 2-hydroxy-17beta-estradiol
CFAMM00089087 DNC003240 Investigative Drug 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE
CFAMM00089231 DNC006179 Investigative Drug 16-(2',2'-Dimethyl)-propylidene-estradiol
CFAMM00089030 DNC000182 Investigative Drug Alpha-estradiol
CFAMM00089078 DNC006190 Investigative Drug 16-beta-hydroxymethyl-estradiol
CFAMM00089112 DNC007072 Investigative Drug estradiol 17-O-sulfamate
CFAMM00089219 DNC006191 Investigative Drug 16beta-cyano-estradiol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27066 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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