CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD617
Family Name Histamine H1 receptor Ligand Doxylamine Family
No. of Seeds 2 No. of Other Members 91
Family Centroid CFAMM00089380 Functional Category Approved Drug with Natural Product
Superfamily Histamine H1 receptor Ligand Doxylamine Superfamily
Class Class 484

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Bepotastine Family 2 2
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Citric Acid family 2 58
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Grt 6005/06 family 4 22
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
DNA-dependent protein kinase catalytic subunit Inhibitor 2-(1h... 2 0
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Cytochrome P450 11B1, mitochondrial Inhibitor 5-(6-methoxynaph... 7 4
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family 3 41
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Substance-P receptor ligand (1S,2R)-2-[(1R)-1-[3,5-bis(trifluo... 7 2
Substance-P receptor ligand 1-[4-[[3,5-bis(trifluoromethyl)phe... 3 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 8 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 11 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Lysosomal Pro-X carboxypeptidase inhibitor 5-(4-chloropyridin-... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
Substance-P receptor and Sodium-dependent serotonin transporte... 11 6
Sodium-dependent serotonin transporter and Substance-P recepto... 4 1
Substance-P receptor and Sodium-dependent serotonin transporte... 11 4
Sodium-dependent serotonin transporter and Substance-P recepto... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 1 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 1 0
Glucocorticoid receptor ligand SureCN3894124 family 3 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 7 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Platelet-activating factor receptor ligand SureCN9575051 family 1 0
Thromboxane-A synthase and Prostacyclin synthase inhibitor (Z)... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand [(7S)... 1 3
Extracellular calcium-sensing receptor ligand SureCN14502754 f... 1 0
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00089380 DAP000859 Approved Drug Doxylamine
CFAMM00089342 DAP001069 Approved Drug Carbinoxamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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