CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD619
Family Name Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diethylpropion Family
No. of Seeds 29 No. of Other Members 276
Family Centroid CFAMM00089455 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diethylpropion Superfamily
Class Class 485

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Opioid receptor Ligand Methadone Family 3 39
D(2) dopamine receptor Ligand Haloperidol Family 5 53
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Aldehyde oxidase inhibitor para-naphthoquinone Menadione Family 22 503
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Vitamin K epoxide reductase complex subunit 1 Inhibitor Phenin... 5 44
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
DNA Binder Procarbazine Family 8 358
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Substance-P receptor Ligand Orvepitant Family 11 46
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Chymase Inhibitor Phenylalanylmethane Family 1 8
Cathepsin L1 Inhibitor Biphenyl-4-yl-acetaldehyde Family 2 86
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Carbonic anhydrase 2 Inhibitor N-benzyl-4-sulfamoyl-benzamide ... 12 44
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cytosolic phospholipase A2 Inhibitor 1,1,1,2,2-pentafluoro-8-p... 11 18
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Liver carboxylesterase 1 Inhibitor 1,2-bis(2,3,6-trifluorophen... 16 11
Liver carboxylesterase 1 Inhibitor 1-(4-chloro-phenyl)-2-pheny... 5 47
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
72 kDa type IV collagenase and Macrophage metalloelastase Inhi... 2 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 28
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 4 10
Thyroid hormone receptor beta Ligand 1-(4-hexylphenyl)-3-(prop... 2 1
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 8
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmethylma... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
4-hydroxyphenylpyruvate dioxygenase Inhibitor 2-(2-iodo-benzoy... 3 1
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Neuraminidase Inhibitor (e,e)-1,7-diphenyl-4,6-heptadien-3-one... 2 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
C-C chemokine receptor type 5 ligand AC1NUIO8 family 12 11
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Sigma non-opioid intracellular receptor 1 ligand N-Phprop-clph... 1 12
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Acetylcholinesterase inhibitor AC1MIM21 family 2 7
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
Coagulation factor X and Trypsin-1 inhibitor 3-carbamimidoyl-N... 1 1
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[[... 2 10
Melanin-concentrating hormone receptor 1 ligand 1-(3-acetyl-1,... 8 4
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 7 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-(4-oxo-4-ph... 1 0
D(2) dopamine receptor and Sigma non-opioid intracellular rece... 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 7 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 11 2
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
Nociceptin receptor and Kappa-type opioid receptor ligand Pipe... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
5-hydroxytryptamine receptor 1A ligand [(7S,8R)-7-(dipropylami... 4 0
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 5
Plasmepsin-2 inhibitor SureCN8292428 family 1 2
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Lanosterol synthase and Cycloartenol synthase inhibitor (4-bro... 1 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 22
Cathepsin S and Cathepsin L1 inhibitor (Z,3S)-1-diazonio-3-[[2... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TEL... 1 7
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 1 0
Lanosterol synthase and Squalene--hopene cyclase inhibitor AGN... 2 5
Arachidonate 5-lipoxygenase inhibitor (Z)-3-[hydroxy(methyl)am... 1 4
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 1 1
Tyrosine-protein kinase Lck inhibitor 1-[2-[bis[3-[bis[3-[bis(... 1 0
Arachidonate 5-lipoxygenase inhibitor (Z)-1-(4-chlorophenyl)-3... 1 0
Putative fructose-1,6-bisphosphate aldolase and Nuclear recept... 1 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00089455 DAP000862 Approved Drug Diethylpropion
CFAMM00089556 DNC010128 Investigative Drug 2-(tert-Butylamino)-3'-fluoropropiophenone
CFAMM00089487 DNC006220 Investigative Drug 1-(3-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one
CFAMM00089723 DNC007836 Investigative Drug 3-(dibutylamino)-1-(4-hexylphenyl)propan-1-one
CFAMM00089555 DNC010120 Investigative Drug 2-(N-tert-Butylamino)propiophenone
CFAMM00089486 DNC006223 Investigative Drug 4-(2-pyrrolidin-1-yl-pentanoyl)benzonitrile
CFAMM00089722 DNC007835 Investigative Drug 3-(dimethylamino)-1-(4-hexylphenyl)propan-1-one
CFAMM00089537 DNC009794 Investigative Drug 3-(dimethylamino)-1-(4-heptylphenyl)propan-1-one
CFAMM00089617 DNC010477 Investigative Drug 2-(N-Cyclopentylamino)-3'-methylpropiophenone
CFAMM00089491 DNC006225 Investigative Drug 1-(4-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one
CFAMM00089536 DNC000138 Investigative Drug AC-42
CFAMM00089594 DNC006218 Investigative Drug PYROVALERONE
CFAMM00089553 DNC010122 Investigative Drug 2-(N,N-Diethylamino)-3'-chloropropiophenone
CFAMM00089514 DNC010465 Investigative Drug 2-(N-Pyrrolidinyl)-3'-fluoropropiophenone
CFAMM00089463 DNC004123 Investigative Drug (1-Phenethyl-piperidin-4-yl)-phenyl-methanone
CFAMM00089616 DNC010476 Investigative Drug 2-(N-Pyrrolidinyl)-3'-bromopropiophenone
CFAMM00089664 DNC006743 Investigative Drug 1-benzoyl-2-benzyl-1,2-dihydropyridin-3(6H)-one
CFAMM00089490 DNC006224 Investigative Drug 1-(3-iodophenyl)-2-pyrrolidin-1-yl-pentan-1-one
CFAMM00089513 DNC010466 Investigative Drug 2-(N-Pyrrolidinyl)-3'-methylpropiophenone
CFAMM00089671 DNC010116 Investigative Drug 1-(3-chlorophenyl)-2-(dimethylamino)propan-1-one
CFAMM00089686 DNC006221 Investigative Drug 1-(2-methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one
CFAMM00089615 DNC010475 Investigative Drug 2-(N-Cyclopentylamino)-3'-fluoropropiophenone
CFAMM00089750 DNC010178 Investigative Drug 2-(tert-butylamino)-1-p-tolylpropan-1-one
CFAMM00089489 DNC006227 Investigative Drug 1-(4-fluorophenyl)-2-pyrrolidin-1-yl-pentan-1-one
CFAMM00089437 DNC010130 Investigative Drug 1-(3-chlorophenyl)-2-(piperidin-1-yl)propan-1-one
CFAMM00089482 DNC006228 Investigative Drug 2pyrrolidin-1-yl-1-phenylpentan-1-one
CFAMM00089488 DNC006226 Investigative Drug 1-(4-bromophenyl)-2-pyrrolidin-1-yl-pentan-1-one
CFAMM00089749 DNC010179 Investigative Drug 2-(tert-Butylamino)-3',5'-difluoropropiophenone
CFAMM00089621 DNC010479 Investigative Drug 2-(tert-butylamino)-1-m-tolylpropan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45110 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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