CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD621
Family Name Tumor necrosis factor Inhibitor Thalidomide Family
No. of Seeds 3 No. of Other Members 50
Family Centroid CFAMM00089846 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Tumor necrosis factor Inhibitor Thalidomide Superfamily
Class Class 486

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Mephenytoin... 5 51
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Diet... 29 276
DNA Binder Procarbazine Family 8 358
Serum albumin Inhibitor Ebselen Family 3 62
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Bavisant family 9 65
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Poly [ADP-ribose] polymerase 1 Inhibitor 3,4-dihydro-5-methyl-... 3 2
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Integrin beta-3 Inhibitor L-709780 Family 9 10
Cruzipain Inhibitor 5-chloro-1-(4-chloro-benzyl)-1h-indole-2,3... 3 13
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Caspase-3 Inhibitor 2-phenethylisoquinoline-1,3,4-trione Family 6 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Liver carboxylesterase 1 Inhibitor 7-(trifluoromethyl)-1h-indo... 1 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 2 23
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Alcohol dehydrogenase [NADP(+)] and Aldose reductase Inhibitor... 3 12
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M5 Ligand VU0119498 Family 1 3
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 80
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Kappa-type opioid receptor ligand 6-[2-oxo-2-[(2S)-2-(pyrrolid... 6 4
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S,5S)-4-(1,3-dih... 3 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acety... 15 9
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
5-hydroxytryptamine receptor 1A ligand U93385 family 4 1
Metabotropic glutamate receptor 5 ligand SureCN504295 family 1 7
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Peptide deformylase inhibitor (2S)-N-benzoyl-1-[(2R)-2-(cyclop... 2 2
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 162
Prothrombin inhibitor N-[7-amino-1-[2-(4-carbamoylphenyl)ethyl... 8 1
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
Prolyl endopeptidase inhibitor 2-{3-[(2s)-4,4-Difluoro-2-(Pyrr... 2 2
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
Caspase-3 and Caspase-7 inhibitor AGN-PC-00BUR6 family 2 1
Caspase-3 inhibitor Benzamide, 3-nitro-N-(1,2,3,4-tetrahydro-1... 2 3
Beta-lactamase inhibitor CHEMBL1406823 family 1 1
Lethal(3)malignant brain tumor-like protein 1 and Kelch-like E... 2 1
Isoindoles and Derivatives Metabolite Folpet Family 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00089846 DAP000865 Approved Drug Thalidomide
CFAMM00089867 DAP001255 Approved Drug Lenalidomide
CFAMM00089889 DNCL002065 Clinical Trial Drug POMALIDOMIDE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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