CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD638
Family Name Alpha adrenergic receptor Ligand Bevantolol Family
No. of Seeds 4 No. of Other Members 48
Family Centroid CFAMM00090770 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily monoamine reuptake and receptor binding Fluoxetine Reboxetine Bevantolol Nebivolol Superfamily
Class Class 149

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Beta-2 adrenergic receptor Ligand Bambuterol Family 4 9
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta adrenergic receptor Ligand Metipranolol Family 5 1
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Zucapsacin family 7 177
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Muscarinic acetylcholine receptor M1 Ligand GSK573719 Family 2 0
Extracellular calcium-sensing receptor Ligand Ronacaleret Family 2 9
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
Beta-3 adrenergic receptor Ligand Amibegron Family 8 46
Substance-P receptor Ligand DA-5018 Family 14 73
Translocator protein Inhibitor Dextofisopam Family 3 250
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Vernakalant family 1 1
Acolbifene family 10 115
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Potassium voltage-gated channel subfamily H member 2 Ligand Al... 2 3
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Extracellular calcium-sensing receptor and Potassium voltage-g... 3 11
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Beta-3 adrenergic receptor Ligand BMS-196085 Family 18 72
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tubulin beta chain Inhibitor Colchinol Family 3 109
5-hydroxytryptamine receptor 2A Ligand (s)-(-)-(4,5,6-trimetho... 3 1
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 5 2
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 2 2
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Extracellular calcium-sensing receptor and Sodium-dependent no... 2 2
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 6 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
Transient receptor potential cation channel subfamily V member... 14 7
5-hydroxytryptamine receptor 1A and Sodium-dependent noradrena... 2 0
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Histamine H3 receptor ligand SureCN6071181 family 2 1
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Muscarinic acetylcholine receptor M5 and Muscarinic acetylchol... 1 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Transient receptor potential cation channel subfamily V member... 4 40
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 10 8
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 0
Sodium-dependent noradrenaline transporter and Cytochrome P450... 11 2
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor Sure... 4 4
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
Membrane primary amine oxidase inhibitor 2-[amino(methyl)amino... 2 0
Beta-lactamase inhibitor CHEMBL1316873 family 1 1
Adenosine receptor A2a and Adenosine receptor A2b ligand N-(2-... 3 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC04029538 Family 3 0
NP N-(3,4-dimethoxyphenethyl)-2-(2-(hydroxymethyl)-5-methoxy-4... 1 0
Putative NP ZINC19322380 Family 2 2
1,4,4a,5,6,8a-hexahydropyrimido[4,5-d]pyrimidine-2,7-dione NP ... 12 0
Putative NP ZINC08453899 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00090814 DNAP001481 Approved Drug Denopamine
CFAMM00090770 DAP000897 Approved Drug Bevantolol
CFAMM00090786 DNC000926 Investigative Drug Metanephrine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543