CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD644
Family Name Type-1 angiotensin II receptor Ligand Eprosartan Family
No. of Seeds 36 No. of Other Members 176
Family Centroid CFAMM00091100 Functional Category Approved Drug
Superfamily Type-1 angiotensin II receptor Ligand Eprosartan Superfamily
Class Class 501

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Candesartan Family 3 75
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Olmesartan Family 13 65
Eluxadoline family 4 85
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Bombesin receptor subtype-3 ligand AGN-PC-07ZAKV family 13 23
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 11
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 7 3
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 5 0
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[[4-[(2-c... 3 1
Carboxypeptidase B2 and Carboxypeptidase B inhibitor 3-(6-amin... 5 10
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 25
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 5 14
Cytochrome P450 26A1 and Cytochrome P450 3A4 inhibitor AGN-PC-... 5 17
NS5B protein inhibitor (2E)-1-cyclohexyl-2-(2-fluoro-4-oxocycl... 2 10
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Neuropeptide Y receptor type 5 ligand SureCN4170426 family 4 13
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 3-methyl-4... 15 14
Lysine--tRNA ligase inhibitor 4-[[2-(2-piperazin-1-ylpyridin-4... 2 0
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
Type-1 angiotensin II receptor and Type-1A angiotensin II rece... 3 0
Thromboxane-A synthase inhibitor Imitrodast family 1 6
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 6
Type-1 angiotensin II receptor ligand 2-butyl-3-[[4-(2-carboxy... 1 7
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Thromboxane-A synthase inhibitor AGN-PC-00NE84 family 1 4
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
Thromboxane-A synthase inhibitor AGN-PC-00NE85 family 1 2
Histamine H3 receptor ligand [3-methyl-2-[(1-propan-2-ylpiperi... 5 3
Neuropeptide Y receptor type 5 ligand AGN-PC-077LX1 family 8 1
Type-1A angiotensin II receptor ligand 2-[4-[[2-butyl-5-(tert-... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 0
Thromboxane-A synthase inhibitor SureCN11474904 family 1 6
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 20
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
Type-1 angiotensin II receptor ligand AGN-PC-025PHO family 3 21
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00091055 DAP001367 Approved Drug Eprosartan mesylate
CFAMM00091100 DAP000908 Approved Drug Eprosartan
CFAMM00091147 CHEMBL122443 Bioactive 4-[[5-[(Z)-[3-[(2-amino-1,3-thiazol-4-yl)methyl]-1-butyl-2,5-dioxoimidazolidin-4-ylidene]methyl]-2-butylimidazol-1-yl]methyl]benzoic acid
CFAMM00091062 CHEMBL419421 Bioactive methyl 5-[[(5Z)-3-butyl-5-[[2-butyl-3-[(4-methoxycarbonylphenyl)methyl]imidazol-4-yl]methylidene]-2,4-dioxoimidazolidin-1-yl]methyl]thiophene-2-carboxylate
CFAMM00091134 CHEMBL125725 Bioactive 4-[[5-[(E)-[3-[(2-amino-1,3-thiazol-4-yl)methyl]-1-butyl-2,5-dioxoimidazolidin-4-ylidene]methyl]-2-butylimidazol-1-yl]methyl]benzoic acid
CFAMM00091041 CHEMBL341131 Bioactive SureCN9396303
CFAMM00090979 CHEMBL299064 Bioactive SureCN9125164
CFAMM00090951 CHEMBL292892 Bioactive SureCN683835
CFAMM00091126 CHEMBL125958 Bioactive SureCN9169063
CFAMM00091007 CHEMBL341295 Bioactive SureCN9168624
CFAMM00091060 CHEMBL331511 Bioactive SureCN9396467
CFAMM00091073 CHEMBL125383 Bioactive SureCN9165472
CFAMM00091145 CHEMBL56522 Bioactive SureCN682660
CFAMM00091099 CHEMBL339404 Bioactive SureCN9396391
CFAMM00091079 CHEMBL55510 Bioactive SureCN9240794
CFAMM00090970 CHEMBL126037 Bioactive SureCN9166709
CFAMM00091157 CHEMBL123671 Bioactive SureCN9165464
CFAMM00091111 CHEMBL434242 Bioactive 4-[[2-butyl-5-[(Z)-[1-butyl-3-[(5-methylthiophen-3-yl)methyl]-2,5-dioxoimidazolidin-4-ylidene]methyl]imidazol-1-yl]methyl]benzoic acid
CFAMM00091124 CHEMBL126111 Bioactive SureCN9166440
CFAMM00091045 CHEMBL57309 Bioactive SureCN683455
CFAMM00091130 CHEMBL97533 Bioactive SureCN6637138
CFAMM00090997 CHEMBL122966 Bioactive 4-[[2-butyl-5-[(Z)-[1-butyl-3-[(4-methylthiophen-2-yl)methyl]-2,5-dioxoimidazolidin-4-ylidene]methyl]imidazol-1-yl]methyl]benzoic acid
CFAMM00091011 CHEMBL56160 Bioactive (E)-3-[2-butyl-3-[(4-sulfamoylphenyl)methyl]imidazol-4-yl]-2-(thiophen-2-ylmethyl)prop-2-enoic acid
CFAMM00091051 CHEMBL291955 Bioactive SureCN7051753
CFAMM00090975 CHEMBL56211 Bioactive SureCN6966963
CFAMM00091037 CHEMBL294686 Bioactive SureCN7052538
CFAMM00091090 CHEMBL317343 Bioactive SureCN6636924
CFAMM00091116 CHEMBL123568 Bioactive SureCN9168966
CFAMM00091129 CHEMBL56333 Bioactive 4-[[2-butyl-5-[(E)-2-carboxy-4-thiophen-2-ylbut-1-enyl]imidazol-1-yl]methyl]benzoic acid
CFAMM00091109 CHEMBL299954 Bioactive 4-[[2-butyl-5-[(E)-3-(carboxymethylamino)-3-oxo-2-(thiophen-2-ylmethyl)prop-1-enyl]imidazol-1-yl]methyl]benzoic acid
CFAMM00091148 CHEMBL37679 Bioactive SureCN683415
CFAMM00090989 CHEMBL294415 Bioactive SureCN683767
CFAMM00091043 CHEMBL54421 Bioactive 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]-2-phenylbenzoic acid
CFAMM00090967 CHEMBL124925 Bioactive SureCN9166364
CFAMM00091082 CHEMBL56497 Bioactive SureCN6968621
CFAMM00090960 CHEMBL56690 Bioactive 2-[4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]phenyl]benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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