CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD647
Family Name Oestrogen receptor ligand Dienestrol Family
No. of Seeds 35 No. of Other Members 440
Family Centroid CFAMM00091466 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Oestrogen receptor ligand Dienestrol Fosfestrol family
Class Class 502

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Cannabinoid receptor 1 Ligand Marinol Family 32 454
Oestrogen receptor ligand steroid Estradiol derivative Fulvest... 3 64
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Fatty-acid amide hydrolase 1 Inhibitor Propofol Family 5 428
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Estrogen receptor beta Ligand Conjugated Estrogens Family 12 210
Tyrosinase Inhibitor Monobenzone Family 6 197
Oestrogen receptor ligand steroid Estradiol Family 18 147
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Oestrogen receptor Ligand Mestranol Family 2 29
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Danthron family 11 141
taste receptor Ligand Cynarin Family 6 124
Oestrogen receptor ligand Fosfestrol Family 1 20
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
NAD-dependent protein deacetylase sirtuin-1 Inhibitor SRT501 F... 19 88
Translocator protein Inhibitor Dextofisopam Family 3 250
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
TS-071 family 8 36
Glycoprotein IIb/IIIa receptor Ligand Accutin Family 4 24
Arachidonate 5-lipoxygenase Inhibitor Caffeic Acid Family 3 32
Bile acid receptor Ligand SR-45023A (apomine) Family 3 34
Macrophage migration inhibitory factor and Prothrombin Inhibit... 2 49
Estrogen receptor beta Ligand 1-chloro-6-(4-hydroxyphenyl)-2-n... 12 23
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 2 19
Steryl-sulfatase Inhibitor 3-{4-[(aminosulfonyl)oxy]benzoyl}ph... 5 3
Steryl-sulfatase Inhibitor Sulfamic Acid 3-(4-hydroxy-benzoyl)... 3 2
Tyrosine-protein kinase Lck Inhibitor 2-(3,4,5-trihydroxy-benz... 2 6
Epidermal growth factor receptor Ligand AG-538 Family 5 11
Epidermal growth factor receptor Ligand 2-(4,5-dihydroxy-indan... 2 1
Estrogen receptor beta Ligand 3,6-dihydroxy-2-(4-hydroxy-pheny... 2 23
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Oestrogen receptor and Estrogen receptor beta Ligand 1-bromo-6... 3 4
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 5 13
Arachidonate 15-lipoxygenase Inhibitor Hydrohalisulfate 1 Family 6 6
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 21 16
Tubulin beta chain Inhibitor Combretastatin Family 3 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
Steryl-sulfatase Inhibitor 2-ethylestradiol 3,17-o,o-bis-sulfa... 1 2
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Kinesin-like protein KIF11 Inhibitor 4'-(trifluoromethyl)-4-bi... 2 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Neutrophil elastase Inhibitor Bornyl (3,4,5-trihydroxy)-cinnam... 1 0
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-(6-hydroxy-2-nap... 7 9
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 5 8
Arachidonate 12-lipoxygenase, 12S-type and Arachidonate 15-lip... 3 7
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Indoleamine 2,3-dioxygenase 1 Inhibitor Naphthalene-1,4-diol F... 2 4
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor P-coum... 1 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Tyrosinase Inhibitor 4-(6-hydroxynaphthalen-2-yl)benzene-1,3-d... 4 2
Tyrosinase Inhibitor Kazinol S Family 1 0
Tyrosinase Inhibitor 4-adamantyl Resorcinol Family 1 1
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Cannabinoid receptor 1 and Fatty-acid amide hydrolase 1 Ligand... 1 0
Tyrosinase Inhibitor 5,5'-methylenebis(1,3,4-thiadiazole-2(3h)... 2 1
DNA polymerase Inhibitor 3alpha-o-trans-p-coumaroyl-7-labden-1... 1 13
Aromatase inhibitor (3R,4R)-4-benzyl-3-[(3-hydroxyphenyl)methy... 1 10
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Estrogen receptor beta and Estrogen receptor ligand 3-fluoro-4... 6 42
Prelamin-A/C inhibitor CHEMBL1495780 family 1 4
Estrogen receptor and Estrogen receptor beta ligand 10-[(8S,9S... 1 0
Estrogen receptor and Estrogen receptor beta ligand 4-[(E)-4-(... 1 2
Estrogen receptor beta and Estrogen receptor ligand 4-bromo-9a... 3 0
Estrogen receptor beta and Estrogen receptor ligand (4Z)-2-flu... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 14
Estrogen receptor and Estrogen receptor beta ligand 3-[(E)-4-(... 1 3
Androgen receptor and Progesterone receptor ligand diarylpheno... 1 1
Glucocorticoid receptor ligand SureCN4024251 family 1 0
Cellular tumor antigen p53 and Epidermal growth factor recepto... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 0
Lethal factor and Nuclear receptor ROR-gamma ligand CHEMBL1559... 1 2
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3-bromophe... 1 1
Steryl-sulfatase inhibitor (8R,9S,13S,14S,17R)-17-[(3,4-dichlo... 1 3
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Monoglyceride lipase inhibitor 7-(2-hydroxyphenyl)heptane-1-su... 1 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 5-(2-... 3 0
Aldo-keto reductase family 1 member C3 inhibitor (2R,8'R,9'S,1... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Estradiol 17-beta-dehydrogenase 1 inhibitor SureCN4589665 family 2 4
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
Integrase inhibitor AC1O6FK1 family 1 0
Arachidonate 15-lipoxygenase and Nuclear receptor ROR-gamma li... 1 18
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor propan... 3 5
DNA polymerase beta and Thioredoxin glutathione reductase inhi... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 1-[3,... 4 0
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 2,2-d... 1 0
Glutamate carboxypeptidase 2 inhibitor 2-[(3-hydroxyphenyl)met... 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 3
Eukaryotic elongation factor 2 kinase and Proto-oncogene tyros... 1 1
Retinoic acid receptor beta ligand Adarotene family 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 i... 1 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 3
Phenols and Derivatives Metabolite 3,4-Dihydroxyphenylglycol O... 1 1
Toluenes Metabolite p-Cresol sulfate Family 1 5
Acenes Metabolite 2-Methyl-1,4-naphthalenediol bis(dihydrogen ... 2 2
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
2,4-diacetyl-5-hydroxy-3-(4-hydroxyphenyl)-5-methylcyclohexen-... 4 0
NP (1r,2r,4s)-2-(2-methoxyphenyl)-1,3,3-trimethylbicyclo[2.2.1... 3 0
[(E)-3-carboxy-2-(5-methyl-2-oxidophenyl)prop-2-enyl]-(2-pheny... 3 0
NP Agn-pc-05t67i Family 5 0
Putative NP ZINC03197541 Family 1 0
2,4-bis(4-hydroxyphenyl)cyclobutane-1,3-dicarboxylate NP ZINC0... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00091468 DAP001011 Approved Drug Diethylstilbestrol
CFAMM00091760 DAP000913 Approved Drug Masoprocol
CFAMM00091466 DAP001015 Approved Drug Dienestrol
CFAMM00091914 CHEMBL69408 Bioactive AGN-PC-00CQ2C
CFAMM00091705 CHEMBL554507 Bioactive AC1L1WFY
CFAMM00091579 CHEMBL573635 Bioactive Ethylstilbestrol
CFAMM00091913 CHEMBL574524 Bioactive AGN-PC-072YDQ
CFAMM00091473 CHEMBL132919 Bioactive AGN-PC-075MNF
CFAMM00091923 CHEMBL136039 Bioactive 4-[2-(4-hydroxyphenyl)pent-3-ynyl]phenol
CFAMM00091452 CHEMBL334798 Bioactive 4-[2-(4-hydroxyphenyl)but-3-ynyl]phenol
CFAMM00091643 CHEMBL306878 Bioactive AGN-PC-00DL4K
CFAMM00091904 CHEMBL577241 Bioactive 4,4'-Dihydroxybibenzyl
CFAMM00091945 DNC012734 Investigative Drug HEXESTROL
CFAMM00092057 DNC012443 Investigative Drug 4-cycloheptyliden(4-hydroxyphenyl)methylphenol
CFAMM00092005 DNC012472 Investigative Drug 4-cyclohexyliden(4-hydroxyphenyl)methylphenol
CFAMM00091782 DNC012435 Investigative Drug 4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol
CFAMM00091722 DNC004035 Investigative Drug 4-[1-(4-hydroxyphenyl)-2-phenylhex-1-enyl]phenol
CFAMM00091853 DNC004024 Investigative Drug 4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol
CFAMM00091950 DNC012466 Investigative Drug 4-cyclopentyliden(4-hydroxyphenyl)methylphenol
CFAMM00091968 DNC004004 Investigative Drug 4-[2,2-bis(4-hydroxyphenyl)-1-methylvinyl]phenol
CFAMM00091749 DNC005795 Investigative Drug 1,2-Bis-(4-hydroxy-phenyl)-3H-inden-5-ol
CFAMM00091401 DNC004043 Investigative Drug 4-[1-(4-hydroxyphenyl)-2-phenylprop-1-enyl]phenol
CFAMM00091899 DNC004012 Investigative Drug 4-[1,2-bis(4-hydroxyphenyl)pent-1-enyl]phenol
CFAMM00091673 DNC009853 Investigative Drug 5,3'-Dipropyl-biphenyl-2,4'-diol
CFAMM00091967 DNC004002 Investigative Drug 4-[1,2-bis(4-hydroxyphenyl)hex-1-enyl]phenol
CFAMM00091748 DNC001037 Investigative Drug Nordihydroguaiaretic acid
CFAMM00091400 DNC004011 Investigative Drug 4-[1,2-bis(4-hydroxyphenyl)but-1-enyl]phenol
CFAMM00091431 DNC009348 Investigative Drug 1,1':4',1''-terphenyl-3,4''-diol
CFAMM00091399 DNC004044 Investigative Drug 4-[1-(4-hydroxyphenyl)-2-phenylpent-1-enyl]phenol
CFAMM00091738 DNC011444 Investigative Drug 3-[1-ethyl-2-(3-hydroxyphenyl)butyl]phenol
CFAMM00091671 DNC009851 Investigative Drug HONOKIOL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46113 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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