CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD659
Family Name Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family
No. of Seeds 67 No. of Other Members 482
Family Centroid CFAMM00092815 Functional Category Approved Drug with Natural Product
Superfamily Peptide deformylase, mitochondrial Inhibitor Trimethoprim Superfamily
Class Class 513

Cousin Family NamesSeedsMembers
Endothelin B receptor and Endothelin-1 receptor ligand pyrimid... 22 180
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Histamine H1 receptor Ligand Mepyramine Family 5 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Melanin-concentrating hormone receptor 1 Ligand NGD-4715 Family 1 1
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Glucokinase Inhibitor GKA1 Family 2 67
Tyrosine kinase Inhibitor PKI166 Family 17 198
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Peptide deformylase, mitochondrial Inhibitor Brodimoprim-4,6-d... 9 1
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Deoxycytidine kinase inhibitor AGN-PC-07Z9C8 family 5 3
Deoxycytidine kinase inhibitor AGN-PC-07Z9GO family 10 2
Deoxycytidine kinase inhibitor 2-[1-[6-(2-chlorophenoxy)pyrimi... 2 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Leukotriene B4 receptor 1 ligand AGN-PC-07ZF09 family 3 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 4 2
Endothelin-1 receptor ligand AGN-PC-00GZJQ family 12 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 6
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Dihydrofolate reductase inhibitor (E)-3-[5-[(2,4-diaminopyrimi... 3 2
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Proto-oncogene tyrosine-protein kinase Src inhibitor ethyl 2-[... 4 9
Dihydrofolate reductase inhibitor 2-bromo-N-[4-[4-[(2,4-diamin... 1 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 7-fluoro-3-(5-... 2 7
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Mitogen-activated protein kinase kinase kinase 11 and Leucine-... 1 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Dihydrofolate reductase inhibitor 5-[[4-(2,4-dichlorophenyl)-6... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Adenosine kinase inhibitor SureCN8139139 family 1 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 21
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
Dihydrofolate reductase inhibitor 5-[[4-[2-[4-(4-aminophenyl)s... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase inhibitor 1-... 1 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
P2X purinoceptor 3 and P2X purinoceptor 2 inhibitor 2-[[4-amin... 10 9
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[3,4-di... 2 0
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Insulin-like growth factor 1 receptor ligand AGN-PC-044T61 family 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 2
Glucose-dependent insulinotropic receptor ligand tert-butyl 4-... 1 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 1 0
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 2 5
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
P2X purinoceptor 3 and P2X purinoceptor 2 inhibitor 5-[4-metho... 1 1
P2X purinoceptor 3 and P2X purinoceptor 2 inhibitor 5-(4-bromo... 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor AGN-PC-076LAV ... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
Tyrosine-protein kinase Lck and Angiopoietin-1 receptor ligand... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
Fibroblast growth factor receptor 1 and Fibroblast growth fact... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00092815 DAP000927 Approved Drug Trimethoprim
CFAMM00092737 CHEMBL137305 Bioactive 5-[(3-pentoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00093098 CHEMBL261849 Bioactive cFMS Receptor Tyrosine Kinase Inhibitor
CFAMM00092642 CHEMBL14001 Bioactive 6-[5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenoxy]hexanoic acid
CFAMM00093001 CHEMBL174433 Bioactive 5-[(4-ethyl-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00093063 CHEMBL118581 Bioactive AGN-PC-008F8T
CFAMM00092834 CHEMBL115483 Bioactive SureCN11383945
CFAMM00092914 CHEMBL105283 Bioactive TCMDC-137353
CFAMM00092968 CHEMBL13908 Bioactive AGN-PC-0746KC
CFAMM00093029 CHEMBL324775 Bioactive 5-[(3-heptoxy-4-methoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00093117 CHEMBL22139 Bioactive 5-[[3-propoxy-4-[(3,4,5-trimethoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
CFAMM00092826 CHEMBL416373 Bioactive 5-[[3-butoxy-4-[(3,4,5-trimethoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
CFAMM00092763 CHEMBL172805 Bioactive 3-[4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenoxy]propan-1-ol
CFAMM00092641 CHEMBL423434 Bioactive 5-[[4-(4-aminophenoxy)-3,5-dimethoxyphenyl]methyl]pyrimidine-2,4-diamine
CFAMM00093185 CHEMBL418347 Bioactive TCMDC-137359
CFAMM00092884 CHEMBL278345 Bioactive TCMDC-137647
CFAMM00093000 CHEMBL14201 Bioactive 2-[5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenoxy]acetic acid
CFAMM00093178 CHEMBL13673 Bioactive AGN-PC-0746IR
CFAMM00092905 CHEMBL1236788 Bioactive 5-[[(2R)-2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl]methyl]pyrimidine-2,4-diamine
CFAMM00092920 CHEMBL333779 Bioactive 2,4-Pyrimidinediamine, 5-[[3-ethoxy-4-(3-phenylpropoxy)phenyl]methyl]-
CFAMM00092749 CHEMBL21395 Bioactive 2,4-Pyrimidinediamine, 5-[[3-ethoxy-4-(phenylmethoxy)phenyl]methyl]-
CFAMM00092825 CHEMBL416376 Bioactive AGN-PC-00F10K
CFAMM00093081 CHEMBL291931 Bioactive 2,4-Pyrimidinediamine, 5-[[4-methoxy-3-(phenylmethoxy)phenyl]methyl]-
CFAMM00093096 CHEMBL119568 Bioactive 2,4-Pyrimidinediamine, 5-[[4-(3-phenoxypropoxy)phenyl]methyl]-
CFAMM00092708 CHEMBL104369 Bioactive TCMDC-137899
CFAMM00093177 CHEMBL334919 Bioactive 5-[(3-propan-2-yloxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092952 CHEMBL118202 Bioactive 5-[[3-ethoxy-4-[3-(3-phenoxypropoxy)propoxy]phenyl]methyl]pyrimidine-2,4-diamine
CFAMM00093129 CHEMBL13820 Bioactive 3-[5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenoxy]propanoic acid
CFAMM00092824 CHEMBL282022 Bioactive AGN-PC-00OGXO
CFAMM00093005 CHEMBL118652 Bioactive AGN-PC-008QFQ
CFAMM00092856 CHEMBL31547 Bioactive 5-[(3-hexoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092985 CHEMBL427305 Bioactive 5-[(3,5-dimethoxy-4-prop-2-enoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092862 CHEMBL274430 Bioactive TCMDC-137630
CFAMM00093087 CHEMBL119189 Bioactive 2,4-Pyrimidinediamine, 5-[[3-ethoxy-4-(pentyloxy)phenyl]methyl]-
CFAMM00092796 CHEMBL22327 Bioactive AC1LA7IK
CFAMM00093079 CHEMBL318078 Bioactive methyl 6-[4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenoxy]hexanoate
CFAMM00092823 CHEMBL23609 Bioactive TCMDC-137664
CFAMM00092672 CHEMBL303075 Bioactive 4-[(2,4-diaminopyrimidin-5-yl)methyl]-2-(2-hydroxypropyl)-6-methoxyphenol
CFAMM00093017 CHEMBL116183 Bioactive 5-[(3,4,5-triethoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092881 CHEMBL13877 Bioactive TCMDC-138041
CFAMM00092753 CHEMBL119669 Bioactive AGN-PC-00F5T6
CFAMM00092644 CHEMBL14002 Bioactive TCMDC-137356
CFAMM00092977 CHEMBL22901 Bioactive SureCN10057900
CFAMM00092671 CHEMBL22138 Bioactive 5-[[3,4-bis(phenylmethoxy)phenyl]methyl]pyrimidine-2,4-diamine
CFAMM00093038 CHEMBL279509 Bioactive SureCN10912233
CFAMM00093113 CHEMBL263732 Bioactive 5-[(3,5-dimethoxy-4-methylphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092809 CHEMBL419231 Bioactive 2,4-Pyrimidinediamine, 5-[(4-methoxy-3-propoxyphenyl)methyl]-
CFAMM00093154 CHEMBL321942 Bioactive AGN-PC-074VDF
CFAMM00092685 CHEMBL320596 Bioactive AGN-PC-074VEH
CFAMM00093167 CHEMBL105006 Bioactive 6-[4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenoxy]hexanoic acid
CFAMM00092867 CHEMBL1673303 Bioactive (S)-Iclaprim
CFAMM00093031 CHEMBL60069 Bioactive TCMDC-137661
CFAMM00092752 CHEMBL170172 Bioactive 5-[(4-ethoxy-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092828 CHEMBL173901 Bioactive 5-[(4-butoxy-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092970 CHEMBL23338 Bioactive 5-[[3,4-dimethoxy-5-[(E)-prop-1-enyl]phenyl]methyl]pyrimidine-2,4-diamine
CFAMM00092629 CHEMBL22146 Bioactive 83158-06-9
CFAMM00092949 CHEMBL322001 Bioactive ethyl 2-[4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxyphenoxy]acetate
CFAMM00092643 CHEMBL13796 Bioactive TCMDC-137678
CFAMM00092976 CHEMBL176489 Bioactive 5-[[4-(3-chloropropoxy)-3,5-dimethoxyphenyl]methyl]pyrimidine-2,4-diamine
CFAMM00092731 CHEMBL22811 Bioactive 5-[[3-methoxy-4-[(3,4,5-trimethoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine
CFAMM00092886 CHEMBL176217 Bioactive 5-[[4-[3-[4-(dimethylamino)anilino]propoxy]-3,5-dimethoxyphenyl]methyl]pyrimidine-2,4-diamine
CFAMM00093064 CHEMBL118425 Bioactive AGN-PC-007KL5
CFAMM00092771 CHEMBL369211 Bioactive 5-[(4-hexoxy-3,5-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00093180 CHEMBL56282 Bioactive 5-[(3,5-dimethoxy-4-octoxyphenyl)methyl]pyrimidine-2,4-diamine
CFAMM00092786 CHEMBL59946 Bioactive SureCN9828485
CFAMM00093105 CHEMBL119188 Bioactive AGN-PC-0080NX
CFAMM00092662 DCL000840 Clinical Trial Drug Iclaprim

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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